SAFETY OF A 4-HOUR BED REST PROTOCOL AFTER PERCUTANEOUS RENAL BIOPSY IN LOW BLEEDING RISK PATIENTS: A DESCRIPTIVE STUDY

 

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https://storage.unitedwebnetwork.com/files/1099/0146e4a21840d2f4d68d4d7ea5a8bc61.pdf
SAFETY OF A 4-HOUR BED REST PROTOCOL AFTER PERCUTANEOUS RENAL BIOPSY IN LOW BLEEDING RISK PATIENTS: A DESCRIPTIVE STUDY

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Takamasa
Iwakura
Takamasa Iwakura tkms0421@hama-med.ac.jp Hamamatsu University School of Medicine Division of Nephrology Hamamatsu Japan *
Takahiro Ogagwa t.ogawa@hama-med.ac.jp Hamamatsu University School of Medicine Division of Nephrology Hamamatsu Japan -
Yuriko Shiozaki yuriko.s@hama-med.ac.jp Hamamatsu University School of Medicine Division of Nephrology Hamamatsu Japan -
Ayako Chikasue ayako-chi@hama-med.ac.jp Hamamatsu University School of Medicine Division of Nephrology Hamamatsu Japan -
Taro Aoki aoki88@hama-med.ac.jp Hamamatsu University School of Medicine Division of Nephrology Hamamatsu Japan -
Naoko Katahashi kths@hama-med.ac.jp Hamamatsu University School of Medicine Division of Nephrology Hamamatsu Japan -
Sayaka Ishigaki ishigaki@hama-med.ac.jp Hamamatsu University School of Medicine Division of Nephrology Hamamatsu Japan -
Naoko Tsuji ntsuji@hama-med.ac.jp Hamamatsu University School of Medicine Division of Nephrology Hamamatsu Japan -
Shinsuke Isobe isobe58@hama-med.ac.jp Hamamatsu University School of Medicine Division of Nephrology Hamamatsu Japan -
Tomoyuki Fujikura tfuji@hama-med.ac.jp Hamamatsu University School of Medicine Division of Nephrology Hamamatsu Japan -
Naro Ohashi ohashi-n@hama-med.ac.jp Hamamatsu University School of Medicine Division of Nephrology Hamamatsu Japan -
Hideo Yasuda ysdh@hama-med.ac.jp Hamamatsu University School of Medicine Division of Nephrology Hamamatsu Japan -
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Percutaneous renal biopsy (PRB) is essential for diagnosing renal diseases but carries a risk of bleeding. A national survey in Japan reported that 60% of institutions required 16–24 hours of bed rest, 28% required 8–16 hours, and 11% required 4–8 hours, with overnight supine bed rest generally recommended. In contrast, some international centers have adopted protocols allowing ambulation after 4 hours, although evidence regarding their safety remains limited. In this study, we assessed bleeding risk both before and after PRB and examined the safety of a 4-hour supine bed rest protocol in patients judged to be at low risk for bleeding complications.

We conducted a prospective single-center descriptive observational study to evaluate the safety of an abbreviated bed rest protocol after PRB. Eligible patients were adults (≥18 years) with eGFR >30 mL/min/1.73 m², hemoglobin >10 g/dL, blood pressure <160/100 mmHg, platelet count ≥100,000/µL, no coagulopathy, and independent activities of daily living. Eligibility was confirmed by pre-biopsy laboratory and clinical parameters, and by post-biopsy safety checks during the initial observation period. To ensure patient safety, patients who developed post-biopsy complications such as perirenal hematoma ≥40 mL or hematoma expansion on ultrasound at 1 hour post-biopsy, uncontrolled hypertension, gross hematuria, severe flank pain, or unstable vital signs were excluded prior to initiation of the 4-hour ambulation protocol. Patients meeting all criteria were allowed to sit up and ambulate after 4 hours of strict supine bed rest. Outcomes of interest were bleeding complications requiring transfusion or endovascular intervention, symptomatic bleeding, gross hematuria, and prolonged hospitalization.

A total of 93 patients consented, of whom 28 were excluded due to pre-biopsy bleeding risk factors and 2 were excluded because of hematoma expansion on ultrasound at 1 hour post-biopsy. The remaining 63 patients were analyzed. The mean age was 54.3 years (35 men, 28 women). Mean eGFR was 65.4 mL/min/1.73 m². The mean perirenal hematoma volume was 4.4 mL immediately after biopsy and 2.8 mL at 1 hour post-biopsy. Arteriovenous fistulas were detected in 3 cases, and the mean number of needle passes was 3.9. No bleeding complications requiring transfusion or endovascular intervention were observed; no cases of gross hematuria, symptomatic bleeding, or prolonged hospitalization were recorded.

 In this descriptive study, no major bleeding complications were identified among carefully selected low bleeding risk patients. Our findings suggest that a 4-hour bed rest protocol can be safely applied to carefully selected low bleeding risk patients. However, larger studies with greater sample sizes are required to confirm its generalizability.

Kewords