ASSESSMENT OF QUALITY OF LIFE IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING KIDNEY TRANSPLANTATION IN MADAGASCAR

 

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ASSESSMENT OF QUALITY OF LIFE IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING KIDNEY TRANSPLANTATION IN MADAGASCAR

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Eliane Mikkelsen
Ranivoharisoa
Eliane Mikkelsen Ranivoharisoa remikmed2022@gmail.com Joseph Raseta Befelatanana Teaching Hospital Nephrology Department and Hemodialysis Center Antananarivo Madagascar *
Sedera Aurélien Mioaramalala sederamioramalala@gmail.com Limoges Teaching Hospital Inserm U1094, IRD UMR270 Antananarivo France -
Tiffany Rasolofo rhtiffany98@gmail.com Joseph Raseta Befelatanana Teaching Hospital Nephrology Department and Hemodialysis Center Antananarivo Madagascar -
Willy Franck Harilalaina Randriamarotia rfwilly@yahoo.fr Joseph Raseta Befelatanana Teaching Hospital Nephrology Department and Hemodialysis Center Antananarivo Madagascar -
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Kidney transplantation is the treatment of choice for patients with end-stage renal disease, significantly improving the quality of life. It is the most common form of renal replacement therapy worldwide, with over 90,000 transplants performed annually globally. The number of kidney transplants continues to rise, driven by increased awareness, advances in surgical techniques, and improved immunosuppressive therapies. Despite these gains, disparities remain in access to transplantation between regions and populations. In low- and middle-income countries like Madagascar, access to transplantation is limited, affecting patient outcomes. However, transplantation remains a crucial public health intervention given its ability to reduce long-term healthcare costs and enhance patient survival. This study evaluates the quality of life for chronic kidney disease patients under kidney transplantation in Madagascar.

We conducted a cross-sectional, descriptive study over a three-months period, from September 2nd, 2024, to December 6th, 2024, involving kidney transplant recipients at Joseph Raseta-Befelatanana Teaching Hospital and Joseph Ravoahangy-Andrianavalona Teaching Hospital. The quality of life was assessed using a score ranging from 0 (worst) to 100 (best). We included all patients who had undergone kidney transplantation at least six months prior and who had provided informed consent, while excluding incomplete data. During the study, we utilized the Short Form Health Survey-36 (SF-36) and the Renal Transplanted Quality of Life Version 2 (ReTransQoL V2) questionnaires. The SF-36 evaluated overall quality of life across both physical and mental components, each comprising eight dimensions: Physical Functioning (PF), Bodily Pain (BP), Role Limitations due to Physical Health (RP), General Health (GH), and Physical Summary Score (PSC); Mental Health (MH), Social Functioning (SF), Role Limitations due to Mental Health (RE), and Vitality (VT). The ReTransQoL, specific to kidney transplantation, assessed five dimensions: Physical Health (PH100), Treatment (T100), Social Functioning (SFT100), Quality of Care (MC100), and Fear of Graft Loss (FLG100). Data analysis was performed using STATA 13.

Figure N°1. Frequences in percentage (%) according to complications (N=31)


Figure N°2. Quality of life Score according to SF-36 – Physical components (N=31)


Table N°1. Quality of life Score according to ReTransQoL V2 (N=31)

Figure N°3. Quality of life Score according to SF-36 – Mental components (N=31)

The study included 31 Malagasy kidney transplant patients. The median age was 51 years, with extremes of 19 and 69 years. The sex ratio was 2.8. The median duration since transplantation was 36 months, ranging from 6 to 108 months. The most common complications observed were adverse effects of anti-rejection drugs, seen in 56.06% of cases, and infectious complications, seen in 16.13% of cases. Details of postoperative complications are summarized in Figure 1. According to the SF-36, the median score for overall physical quality of life was 76.25, with the highest scores in the "Physical Pain" dimension. The median mental summary score was 83, with the highest scores in the "Mental Limitations" and "Relationships" dimensions. The "Physical Limitations" dimension was slightly affected, with a median score of 50. In the ReTransQoL V2 assessment, the median physical health score was 85. The lowest scores were related to "Quality of Care," at 34,37 and "Fear of Graft Loss," at 41.25. Details regarding quality of life scores from SF-36 and ReTransQoL V2 are presented in Table 1 and Figure 2 and 3.


In conclusion, kidney transplant patients reported a satisfactory quality of life following the procedure. However, to further improve outcomes, key strategies should include increasing awareness, implementing physical rehabilitation programs, and providing comprehensive psychosocial support. Our study highlights the significant impact of kidney transplantation on patients’ quality of life in Madagascar. These findings underscore the urgent need to enhance post-transplant care and expand access to transplantation services. Given the demonstrated benefits, promoting the development of a dedicated renal transplantation program in our region is essential. Such an initiative would not only improve survival rates but also substantially enhance the overall well-being of patients with chronic kidney failure. Establishing this specialty could represent a major step forward in providing better quality of life for these patients.

Kewords