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Immunoglobulin A nephropathy (IgAN) and immunoglobulin A vasculitis (IgAV) have been reported to be related diseases, but the relationship is not fully defined. Cutaneous purpura is the mandatory criterion for the diagnosis of IgAV.
We report the first case of IgAV triggered by opportunistic Klebsiella pneumonia infection associated with methylprednisolone pulse therapy, which was intended to be the treatment of IgAN.
There were clinical cases reported episodes of IgAN and IgAV in the same patient, in homozygous twins, and the kidney allograft. There were also several kinds of infectious triggers of IgAN and IgAV being reported. To our knowledge, this is the first case of IgAV triggered by opportunistic Klebsiella pneumonia infection associated with methylprednisolone pulse therapy, which was intended to be the treatment of IgAN.