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It is suggested that the progression of chronic kidney disease (CKD), proteinuria, and replacement therapy influence the derangement of the lipoproteins metabolism. These factors affect the composition and functionality of lipoproteins, including their subfractions. Given the importance of cardiovascular disease in patients with CKD, several nutritional strategies have been proposed to improve this outcome, such as resistant starch (RS) supplementation. However, to the best of our knowledge, no study has evaluated the effect of the consumption of RS on high-density lipoprotein (HDL) and low-density lipoprotein (LDL) subfractions. Thus, this study aimed to evaluate whether RS consumption would alter the lipoproteins subfraction in patients with CKD undergoing hemodialysis (HD).
This was a randomized, double-blind, placebo-controlled trial in which the patients were allocated to the RS group to receive alternately 9 cookies/day (dialysis days) and 1 sachet/d (non-dialysis days) containing 16g/d of RS (Hi-Maize 260, Ingredion®) or placebo group to receive manioc flour, for 4 weeks. HDL and LDL subfractions were determined using the standardized Lipoprint® system (Quantimetrix Inc., Redondo Beach, California).
Forty participants finished the study: 19 in the RS group (71.4% female; 53 (11) years and 45 (27) months HD vintage) and 21 in the placebo group (36.8% female; 56 (11) years and 36 (49) months HD vintage). At baseline, groups presented lipoprotein subfractions without significant differences (Table 1). However, the RS supplementation could not change the plasma levels of the lipoprotein subfractions (Figure 1).
RS supplementation did not change the lipoprotein subfractions significantly, suggesting being ineffective after 4 weeks.
Funding Sources/Commercial Support: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ).