VALIDITY OF RENAL DOPPLER RESISTIVITY INDEX IN RENAL ALLOGRAFT INFECTION

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FATTHY

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Abdelrahman Marzouk Abdo.elmaghraby75@gmail.com Cairo University Faculty of medicine Nephrology Cairo

Co-author 2

Ahmed Fathy ahmednephrology@yahoo.com Cairo University Nephrology Cairo

Co-author 3

Ahmed Fayed dr.fayed@gmail.com Cairo University faculty of medicine Nephrology Cairo

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Introduction

Doppler ultrasonography is usually used by many clinicians throughout follow-up to detect high-risk patients without determining the actual cause of graft dysfunction. Although few studies demonstrating a correlation between intrarenal resistive index (RRI) and renal function in patients with kidney diseases, correlations between RI and renal histopathology characteristics especially infected allograft have not been thoroughly investigated in renal transplant recipients.

Methods

To study the correlation between RI and renal allograft infection in Kasr Al Ainy school of medicine, Cairo University, Egypt. In a single-center, prospective study involving 109 renal-allograft recipients, the intrarenal RI was evaluated in 109 renal transplant recipients to be correlated with renal allograft infection that was proved in Infected group n : 64 by laboratory and histopathological finding and Non-infected group n:45 without laboratory or histopathological evidence of allograft infection

Results

There was statistically significant difference regarding RI in suspecting allograft infection, ROC curve for detection of infection using RI showed AUC (0.634), P value (0.015), cut off value (0.765) ,(CI:0.527-0.742) , specificity (64.4%) and sensitivity (68.8%) . Causes of allograft infection were CMV in (30.3%), UTI in (18.3%),) and BK polyomavirus in (10.1%).

Conclusions

Renal graft arterial resistivity index normal values despite renal allograft dysfunction may predict graft infection and may help to guide histopathologists for better biopsy interpretation.

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