ONLINE HEMODIAFILTRATION IS MORE EFFICIENT THAN HIGH FLOW HEMODIALYSIS IN THE CLEARANCE OF MEDIUM WEIGHT MOLECULES RENDERING AS BETA 2 MICROGLOBULIN.

E-Poster

https://storage.unitedwebnetwork.com/files/1099/30b8c8809e545ef71c638c5289f36e29.pdf

Abstract Title

First Name *

María Soledad

Last Name *

Lecueder

Co-author 1

Ricardo Silvariño rsilvarino@gmail.com Centro de Nefrologia, Hospital de Clinicas, Facultad de Medicina Nefrologia Montevideo

Co-author 2

Florecia Brovetto flobrovetto@gmail.com Centro de Nefrologia, Hospital de Clinicas, Facultad de Medicina Nefrologia Montevideo

Co-author 3

Cecilia Baccino baccinocecilia@yahoo.com Centro de Nefrologia, Hospital de Clinicas, Facultad de Medicina Nefrologia Montevideo

Co-author 4

Sofia San Román ferrisanroman@gmail.com Centro de Nefrologia, Hospital de Clinicas, Facultad de Medicina Nefrologia Montevideo

Co-author 5

Oscar Noboa onoboa@gmail.com Centro de Nefrologia, Hospital de Clinicas, Facultad de Medicina Nefrologia Montevideo

Co-author 6

Co-author 7

Co-author 8

Co-author 9

Co-author 10

Co-author 11

Co-author 12

Co-author 13

Co-author 14

Co-author 15

Introduction

Hemodialysis is the renal replacement therapy (RRT) most used in the world. Online hemodiafiltration (OL-HDF) and high-flux hemodialysis (HF-HD) techniques demonstrated to be superior in the removal of medium molecular weight (MW) molecules with respect to conventional hemodialysis (CHD). These molecules are linked to an increased risk of cardiovascular events and death. Beta 2 microglobulin (B2M) is a medium PM molecule, in addition to being toxic, it is an example of the concentration of multiple molecules of the same group. Convective techniques such as HDF-OL reduce mortality compared to CHD with the elimination uremic toxins. Aim. Evaluate the efficiency of OL-HDF in removing molecules from medium weight compared to HF-HD.

Methods

Methods: Prospective, descriptive, non-interventional study. Dialysis procedures, ≥ 18 years old, on chronic dialysis, under treatment with AF-HD and OL-HDF modalities, were included. Those with infectious events, dysfunctional angioaccess, residual diuresis >1000 cc/day and RRT time <8 hours/week were excluded. ELISIO-TMH, Nipro® dialyzers were used for the procedures. Clinical and analytical data were obtained. Urea, creatinine, phosphorus, C-reactive protein (CRP) and B2M were measured in each case pre- and post-dialysis. In cases where two measurements were performed, they were separated in time by ≥6 months. Data was recorded for each procedure: time (To), blood pump flow (FB), indicated ultrafiltration (UF), replacement volume in the case of HDF-OL and Kt/V (Figure 1). The work was approved by the ethics committee.

Results

Results: Forty-one procedures were included in the analysis: 22 HF-HD and 19 OL-HDF. Both populations had similar characteristics (Table 1). The time on RRT was longer in patients on HDF-OL vs HD-AF (49.6 ± 32.3 months vs 127.9 ± 69.3, p 0.000).

Conclusions

Conclusion: OL-HDF was more effective than HF-HD in removing medium MW molecules represented by B2M. This benefit was present in each procedure, and was greater in patients with more time in the technique. Given the known impact of medium PM molecules on cardiovascular morbidity and mortality, convective techniques add this additional benefit to the population undergoing chronic dialysis treatment

E-Poster Format Requirements

PDF file
Layout: Portrait (vertical orientation)
One page only (Dim A4: 210 x 297mm or PPT)
E-Poster can be prepared in PowerPoint (one (1) PowerPoint slide) but must be saved and submitted as PDF file.
File Size: Maximum file size is 2 Megabytes (2 MB)
No hyperlinks, animated images, animations, and slide transitions
Language: English
Include your abstract number
E-posters can include QR codes, tables and photos