ACUTE KIDNEY INJURY AFTER LIVER TRANSPLANT , A CENTER REPORT

Back

E-Poster

Abstract Title

First Name *

Saghar

Last Name *

Chehrazi

Co-author 1

Mehdi ghasemi mhdighasemi1990@gmail.com Iran University of Medical Science nephrology Tehran

Co-author 2

Mohsen Reza Mansoorian mansoorian_mr@yahoo.com Iran University of Medical Science Liver transplant Tehran

Co-author 3

shokofeh savaj ssavaj@hotmail.com Iran University Of Medical Science Nephrology(corresponding Author) Tehran

Co-author 4

Co-author 5

Co-author 6

Co-author 7

Co-author 8

Co-author 9

Co-author 10

Co-author 11

Co-author 12

Co-author 13

Co-author 14

Co-author 15

Introduction

Acute kidney injury (AKI) represents a critical complication in the context of liver transplantation, contributing significantly to post-operative morbidity and mortality. Liver transplantation (LTx), as a life-saving procedure for end-stage liver disease, often involves complex hemodynamic and metabolic changes that can predispose patients to AKI. We present the prevalence of AKI, risk factors, and outcomes associated with liver transplant recipients in 192 patients who were transplanted from June 2019 To July 2023 in Firoozgar Hospital.

Methods

The study group was 192 liver transplant recepients , 120 male (62.5%) and 72 female (37.5%) with a mean age 44.5± range 7-75 Years. AKI was defined as any change in serum creatinine 0.3 mg/dL in < 48 h for 5 days after LTx. eGFR was calculated based on CKD-Epi 2021 with the mean range of 94.9±34.3 cc/min. We evaluated demographic data and any history of diabetes, hypertension, chronic kidney disease, nephrotoxic drugs, massive bleeding, need to receive vasopressor drug, liver failure etiology, respiratory assistance, sepsis, any indication for readmission in the operating room, MELD score and liver function after LTx as the risk factors of AKI. The outcome was defined as death in one month after LTx. Data was analyzed with the Spss program version 24.

Results

AKI happened in 105 (54.7%) patients and the mortality rate was 19.3% (37). LTx mortality was correlated with female gender, AKI, patient’s age, bleeding volume, MELD(Model for End -Stage Liver Disease) score, and admission duration (P<0.05). The risk factors for AKI in the univariate analysis were massive bleeding and need for blood transfusion, receiving vasopressors, readmission in the operating room, duration on ventilatory support, baseline eGFR, and impaired liver function tests (P<0.05). Multivariate analysis proved that the baseline eGFR, duration on ventilatory support, need for vasopressors and bleeding volume were the main risk factors for AKI after LTx in this study (P<0.05).

Conclusions

This study supports that the main risk factors for AKI after LTx are hemodynamic factors. A deeper understanding of the complex interplay between liver transplantation and kidney injury improves our outcomes in this high-risk population.

E-Poster Format Requirements

PDF file
Layout: Portrait (vertical orientation)
One page only (Dim A4: 210 x 297mm or PPT)
E-Poster can be prepared in PowerPoint (one (1) PowerPoint slide) but must be saved and submitted as PDF file.
File Size: Maximum file size is 2 Megabytes (2 MB)
No hyperlinks, animated images, animations, and slide transitions
Language: English
Include your abstract number
E-posters can include QR codes, tables and photos