EVALUATION OF DIALYSIS DOSE FOR HOME HEMODIALYSIS PATIENTS -COMPARISON BETWEEN HEMODIALYSIS PRODUCT AND UREA STANDARD Kt/V-

E-Poster

https://storage.unitedwebnetwork.com/files/1099/28938aabde5550c4ad1fa8dd56d51c97.pdf

Abstract Title

First Name *

Masaki

Last Name *

Hara

Co-author 1

Kumiko Momoki momokikumiko@gmail.com Tokyo Dialysis Frontier Ikebukuro Station North Clinic Department of Nephrology Tokyo

Co-author 2

Himiko Shimizu himiko.shimizu@gmail.com Tokyo Dialysis Frontier Ikebukuro Station North Clinic Department of Nephrology Tokyo

Co-author 3

Erika Yamaguchi erika.yamaguchi@gmail.com Tokyo Dialysis Frontier Ikebukuro Station North Clinic Department of Nephrology Tokyo

Co-author 4

Haruna Tanaka haruna.tanaka@gmail.com Tokyo Dialysis Frontier Ikebukuro Station North Clinic Department of Nephrology Tokyo

Co-author 5

Hirofumi Nishida hirofumi.nishida@gmail.com Tokyo Dialysis Frontier Ikebukuro Station North Clinic Department of Nephrology Tokyo

Co-author 6

Takeshi Tokoroyama tokoro1024@gmail.com Tokyo Dialysis Frontier Ikebukuro Station North Clinic Department of Nephrology Tokyo

Co-author 7

Co-author 8

Co-author 9

Co-author 10

Co-author 11

Co-author 12

Co-author 13

Co-author 14

Co-author 15

Introduction

The number of home hemodialysis (HHD) patients in Japan is reported to be 748 (about 0.2% of all dialysis patients), which is small compared to about 2% in the United States. Currently, Japan is making a national effort to promote HHD. Although KDOQI recommends the use of standard Kt/Vurea (stdKt/V) as an index for evaluating the dialysis dose of HHD, hemodialysis product (HDP) is used as a more convenient index because stdKt/V is complicated to calculate in a clinical setting. However, the relationship between these indices is not clear, so we investigated the relationship between HDP and stdKt/V, and the predictive ability and cutoff values of stdKt/V for HDP 72, 108 or higher, which is considered the optimal dialysis dose for HHD patients. We also examined the predictive ability of HDP for the highest third quartile of stdKt/V and the cutoff value.

Methods

A cross-sectional study of 30 patients undergoing HHD at our hospital as of the end of September 2023. Patient age, gender, dialysis vintage, presence or absence of complications, stdKt/V, and HDP were investigated. stdKt/V was calculated using Solute-Solver, version 2.14, an open source program created by Daugirdas et al. Spearman's rank correlation coefficient was used for the correlation between HDP and stdKt/V. The predictive ability of stdKt/V for HDP 72≤ and 108≤ was evaluated using the area under the receiver operating characteristic (ROC) curve (AUC), and cutoff values were calculated. In addition, the predictive ability of HDP for the highest tertile of stdKt/V was evaluated using the AUC, and cutoff values were calculated. Data are presented as mean ± standard deviation.

Results

Conclusions

HDP and stdKt/V showed a significant positive correlation, and the dialysis dose to achieve HDP 72 and 108 or higher was considered to be 3.10 and 4.55 or higher for stdKt/V, respectively. These results suggest a significant positive correlation between HDP and stdKt/V, as well as a reference value of stdKt/V when evaluating the dialysis dose of HHD patients by HDP.

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