ASSOCIATION BETWEEN 25-HYDROXYVITAMIN D, 25(OH)D AND INFLAMATION IN CHRONIC KIDNEY DISEASE

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https://storage.unitedwebnetwork.com/files/1099/774c32a38f4599883d75b46761c27625.pdf

Abstract Title

First Name *

Milica

Last Name *

Petrovic

Co-author 1

Violeta Rabrenovic violettarab@gmail.com Military Medical Academy Clinic of nephrology Belgrade

Co-author 2

Dejan Pilcevic dejan.pilcevic@gmail.com Military Medical Academy Clinic of nephrology Belgrade

Co-author 3

Neven Vavic nvavic@gmail.com Military Medical Academy Clinic of nephrology Belgrade

Co-author 4

Co-author 5

Co-author 6

Co-author 7

Co-author 8

Co-author 9

Co-author 10

Co-author 11

Co-author 12

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Co-author 15

Introduction

Introduction/Aim: According to recent studies, vitamin D is considered a subclinical marker of inflammation, and associated with the inflammatory factors : systemic immune inflammation index- SII and systemic inflammation response index - SIRI, it is involved in the process of atherogenesis. The aim of the study was to examine the association between vitamin D co-concentration and inflammation biomarkers: neutrophil/lymphocyte ratio-NLR, platelet/lymphocyte ratio - PLR, SII and SIRI in patients with chronic kidney disease (CKD) stage I-V, who did not start dialysis treatment.

Methods

Material and methods: a prospective study analyzed 74 adult patients, aged 56.78 ± 11.27, with CKD who were divided into two groups based on the glomerular filtration rate (GFR): GFR 1, with mild and moderate impairment of renal function, (GFR ≥ 30ml /min/1.73m2) and GFR 2, with more severe (GFR < 30 ml/min/1.73m2). Based on the vitamin D value, they are divided into two groups: group I - vit D (< 60 nmol/L), group II - vit D (≥ 60 nmol/L). Blood concentrations of vitamin D were determined and correlated with inflammation markers: NLR, PLR, SII and SIRI.

Results

Results: Analyzing the value of vitamin D in patients with CKD, a significant statistical difference (p < 0.0001) was observed between the groups. Patients with lower GFR values also had lower vitamin D values. In patients with lower vitamin D values, a significant statistical difference was observed for the following parameters: NLR (p < 0.0003), PLR (p < 0.0001), SII (p < 0.0080 ), PTH (p < 0.0001), ALP (p < 0.0389), Ca (p < 0.0003), P (p < 0.0197), proteinuria (p < 0.0001). By examining the association between obesity and vitamin D hypovitaminosis, a statistical difference was observed (p < 0.0369).

Conclusions

Conclusion: Early detection of hypovitaminosis vitamin D, which, in addition to the factor of renal osteodystrophy, is also associated with biomarkers of inflammation in patients with CKD, would contribute to the recognition and treatment of patients at risk for progression of CKD and the development of its complications, as it can represent a subclinical marker of inflammation

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