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Acid-base disturbances reflect changes in a subject's health-disease continuum. Current models explain disturbances by applying mathematical formulas to a set of numerical values in a blood gas analysis report. This often leads to confusion, information overload and healthcare professionals disliking or avoiding the subject.
The Biochemical Approach presents a new system, reworked from the ground up, classifying cellular processes in two groups: cellular respiration (ATP production) and metabolism (substance transport through membrane channels).
Literature review for a theoretical proposal under a different paradigm.
All high Anion Gap disturbances are related to alterations in cellular respiratory processes.
All normal Anion Gap disturbances are related to alterations in ion transport through membrane channels.
The author proposes a simple, three-step algorithm for understanding, interpretation and treatment of acid-base disturbances through blood gas analysis.
The Biochemical Approach of acid-base disturbances provides a linear system that connects cellular processes to their biochemical and clinical manifestations. This provides the healthcare professional with simple, straightforward algorithms for therapeutical decisions.
This abstract has been published in the Colombian Nephrology Journal, july 25th 2023 - https://revistanefrologia.org/index.php/rcn/article/view/612/1060This work has been presented as a poster in the Central American and Caribbean Nephrology Society (SLANH / ASCOLNEF) regional congress in San José, Costa Rica, September 1-2 2023.