THE PREVALENCE AND DEGREE OF HYPERKALAEMIA IN ADULT PATIENTS WITH CHRONIC KIDNEY DISEASE IN DURBAN, SOUTH AFRICA: IS THERE A NEED FOR POTASSIUM LOWERING AGENTS?

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Abstract Title

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Alain

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Assounga

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Tasmeen Bux janepad@ialch.co.za University of KwaZulu-Natal Nephrology Durban

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Introduction

The presence of hyperkalaemia is a known risk factor for the development of cardiac rhythm disturbances and sudden cardiac death. The presence of chronic kidney disease (CKD) is also an independent risk factor for cardiovascular complications. The prevalence of hyperkalaemia in patients with CKD has previously varied widely between studies. The prevalence of hyperkalaemia in the patients attending the renal clinic at Inkosi Albert Luthuli Central Hospital (IALCH) has not been previously determined.

Objectives: This study aimed to discover the prevalence of hyperkalaemia in patients attending the renal clinic at IALCH, as well as the degree of severity amongst the patients in whom hyperkalaemia was present. Demographic and other variables were also assessed for an association with hyperkalaemia.

Methods

A retrospective review of outpatients attending the renal clinic at IALCH from 1 October 2016 until 30 September 2017.

Data collected underwent processing by descriptive statistical methods including mean, median, standard deviation and interquartile range. Logistic regression analysis was performed to assess the association of various variables.

Results

The study consisted of 200 patients, of whom the majority were female (n=120, 60%). The prevalence of hyperkalaemia amongst these patients was found to be 16%. In those with stsage 3 CKD, the prevalence of hyperkalaemia was 7.69%. In those with stage 4 CKD, the prevalence of hyperkalaemia was 20.5% and in those with stage 5 CKD the prevalence was 17.3%. There were no statistically significant associations between hyperkalaemia and demographic variables, nor with dietician intervention. There was a significant association with the use of sodium polystyrene sulfonate.

Conclusions

CKD is a growing burden in the developing world. With CKD comes metabolic and other derangements, including electrolyte abnormalities as well as increased cardiovascular risk. Hyperkalaemia is associated with worsening CKD. In addition, hyperkalaemia puts patients at risk of cardiac dysrhythmias and sudden cardiac death. Pharmacological measures to manage CVD risk should be weighed up against the risk of hyperkalaemia related complications. Potassium lowering agents should be considered in order to allow for optimal CVD management in the setting of hyperkalaemia in CKD.

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