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In renal transplantation, different mechanisms are sought to improve the renal function of the graft. Preclinical studies have identified the upregulation of NAD+ as a potential strategy for the prevention and treatment of AKI (Acute kidney injury). NAD+ is the final metabolized form of vitamin B3. A recent clinical study found that COVID-19 related AKI was associated with NAD+ biosynthetic impairment arising in the context of ischemic, inflammatory, or toxic kidney injury.
Given the unavailability of vitamin B3 in the country, our objective was to determine if I.V. vitamin B complex (vitamin B1, B6 and B12) could improve renal recovery in recipients. By oxidation, vitamin B6 through the pentose phosphate pathway leads to the formation of NADPH (nicotinamide adenine phosphate dinucleotide) and analog of NAD+. (VIBAKY Trial)
A randomized, blinded, placebo-controlled study was performed in renal recipients. During the study, vitamin B complex I.V. or placebo was administered twice daily for 7 consecutive days before and after transplantation. It was evaluated whether vitamin B complex could improve early recovery of renal function.
The normality tests performed showed that the creatinine distributions did not follow a normal trend. In turn, the use of B complex was used as a grouping variable for all the results.
The ratio between the use of B complex and the different categorical variables considered in the analysis was evaluated using the χ2 test of independence or Fisher's exact test, in the case of reduced frequencies in the contingency tables. The value considered as the threshold for rejection of the null hypothesis was 5% (α=0.05). The information was processed in SPSS v. 18 and R v. 4.3.1.
· The most frequent cause of CKD is glomerulonephritis, followed by diabetic kidney disease.
· The most frequent comorbidity is hypertension, followed by diabetes mellitus 2.
· There is no evidence of correlation of comorbidity or other variables recorded, with the use of B complex in the investigation (p>0.05).
· There seems to be no correlation between creatinine values and the use of B complex. The median value is 1.1 mg/d, both for the overall and for the groups considered (p>0.05).
The limitations of the present article are related to the sample size and follow-up time; we consider that the expected results described in the literature were not achieved, so the follow-up of this group of patients will be maintained.