ADHERENCE AND MEDICAL OUTCOMES, IN ADOLESCENTS/YOUNG ADULTS FOLLOWING PEDIATRIC KIDNEY TRANSPLANTATION: A TRANSITION EXPERIENCE BETWEEN TWO PUBLIC TERTIARY HOSPITALS IN ARGENTINA

E-Poster

https://storage.unitedwebnetwork.com/files/1099/81c7315d61b0ec3b190cc14120695ee6.pdf

Abstract Title

First Name *

Last Name *

Gutierrez

Co-author 1

ML Monteverde martamonteverde1@gmail.com Hospital Garrahan Renal Transplant Section Buenos Aires

Co-author 2

J Raño martamonteverde1@gmail.com Hospital Dr Cosme Argerich Deparment of Nephrology Buenos Aires

Co-author 3

N Robledo natalia.robledo3@gmail.com Hospital Garrahan Renal Transplant Section Buenos Aires

Co-author 4

J Ibáñez drjpibanez@gmail.com Hospital Garrahan Renal Transplant Section Buenos Aires

Co-author 5

A Chaparro martamonteverde1@gmail.com Hospital Garrahan Renal Transplant Section Buenos Aires

Co-author 6

R Schiavelli martamonteverde1@gmail.com Hospital Dr Cosme Argerich Deparment of Nephrology Buenos Aires

Co-author 7

Co-author 8

Co-author 9

Co-author 10

Co-author 11

Co-author 12

Co-author 13

Co-author 14

Co-author 15

Introduction

Transition from pediatric to adult care is a critical time, with highest rates of rejection, death with a functioning graft, and graft loss due to non-adherence to immunosuppression.

The aim of this study was to evaluate in kidney transplant pediatric recipients transplanted and followed-up at a public referral center the impact of transition from pediatric to adult health care on medical outcomes and measures of adherence.

Methods

We followed the course of patients who received a Kidney Transplant at Hospital Garrahan and were subsequently transitioned to an adult public hospital (2002-2022). Data were collected from the SINTRA public registry, and from Hospital Garrahan’s, (pediatric) and Argerich’s (adult provider) electronic clinical records.

Results

We included 102 patients, 42% females, with a mean age at transplant of 13.6 years; 95% of them received a deceased donor graft. Main cause of CKD was CAKUT (53%). Mean age at transition was 18.7 y. Mean time of follow up at transition was 5.1 years. At time of transition, 45% had a tacrolimus Coefficient Variation (CV) >25%. (Table 1). Median time of follow-up from transplant time was 8.8 years; (IQR: 6-13) and from transition 3.6y (IQR: 1.9-6.5). Patient and graft survival at 10 years post-transplant were 97% and 75% respectively. Thirty-six (35%) grafts were lost, 47% in the first 3 years post transition. Dividing the cohort according to transplant time in 2 eras: era1 from 2002 to 2015, and era 2, from 2016-2022, graft loss rate after transition decreased from 42.7% (n=32/75) to 14.8% (n=4/27); p=0.009. Main cause of graft loss was rejection (n=30; 83%). Those with a TAC coefficient variation ≥ 25% had higher risk of graft loss (HR: 6.25; CI 95%:1.38 - 28.26), p=0.0017). Three patients died (era 1), 2 with a functioning graft; 2/3 had comorbid- psychiatric illness.

Conclusions

Our findings suggest that time at transition is a period of increased vulnerability for this cohort of pediatric patients, with worse health outcome and decreased adherence. As the approach to transition by both, pediatric and adult teams become stronger, graft loss decreases. It is imperative to identify those adolescents with the highest risk of graft loss.

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