Back
Chronic kidney disease (CKD) is a public health problem. Renal biopsy is considered the gold standard for the diagnosis of diseases that affect the renal parenchyma. In our state, there are a large number of patients with CKD, however, there are few studies that report histopathological findings.
Descriptive cross-sectional study. All patients who underwent renal biopsy at Regional General Hospital 46 with a histopathological report performed in the Pathology Department of the National Medical Center of the West from 2019 to 2022 were included.
146 patients were included, whose characteristics are described in Table 1. The main indications for biopsy were subnephrotic proteinuria and nephrotic syndrome with 17.8% each, followed by proteinuria in the nephrotic range (15.1%), CKD of uncertain etiology (13%). Glomerulopathies were classified as primary in 14.4% and secondary in 85.6%. The most common primary glomerulopathy was focal segmental glomerulosclerosis (FSGS) (38%) followed by IgA nephropathy (29%), membranous nephropathy (NM) (28%) and minimal change disease (5%). The most common secondary glomerulopathy was diabetic nephropathy (39%) followed by FSGS (31%) and lupus nephritis (23%), with ANCA and NM pauci-immune glomerulonephritis being less common (≤5%).
The epidemiology of glomerulopathies is influenced by multiple factors, including the rate and indications for biopsy, geographical conditions, race, sociocultural factors, etc., so it is important to know the causes of glomerular disease in each region. In our study we found that the most common primary glomerulopathy was FSGS, followed by IgA and NM nephropathy. The most common secondary glomerulopathy was diabetic nephropathy, followed by FSGS and lupus nephritis.