Acute kidney injury and electrolyte abnormalities associated with immune checkpoint inhibitors in patients with solid tumours

E-Poster

Abstract Title

First Name *

Dina

Last Name *

Nilasari

Co-author 1

Donnie Lumban Gaol dolumga_51179@yahoo.com Universitas Kristen Indonesia Internal Medicine, Nephrology Department Jakarta

Co-author 2

Daniel Situmorang dr.situmorang@yahoo.co.uk Universitas Kristen Indonesia Internal Medicine, Nephrology Department Jakarta

Co-author 3

Tunggul Situmorang dr.situmorang@yahoo.co.uk Siloam Hospitals MRCCC Nephrology Jakarta

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Introduction

Immune checkpoint inhibitors (ICI) are are now widely used for solid tumours and has improved outcomes for patients with malignant disease. However, despite these improved outcomes, acute kidney injury (AKI) and electrolyte disorder has emerged as an important adverse effects of ICI.

Methods

This was a retrospective cohort study of all patients who received ICIs from Siloam Mochtar Riady Comprehensive cancer center between 2018 and 2023. The follow-up period began at the date of the first ICI exposure and followed for 12 months. The drug classes included in the study were PD-1 and PDL-1 inhibitors. The predictors of acute kidney injury were determined using a multivariate logistic regression model.

Results

A total of 45 Asian Indonesian patients were included. Their average age was 56 years, 61 % are male. There were 12 (26%) patients who developed acute kidney injury after ICI exposure and 10 (22%) patients have hypokalemia, however, none of them have significant hyponatremia. Baseline serum creatinine, comorbidities and ICI type was not associated with AKI. However, lung cancer (OR 1.7; 95% CI 1.1 to 3.8; p=0.05) was associated with AKI.

Conclusions

Lung cancer was associated with acute kidney injury in patients receiving ICI.

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