PREVALENCE OF MUSCULAR ATROPHY IN HEMODIALYSIS PATIENTS WITH SECONDARY HYPERPARATHYROIDISM

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https://storage.unitedwebnetwork.com/files/1099/66d2205b85681edba7f4d4f15ec95ddc.pdf

Abstract Title

First Name *

Myrian

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Cipres

Co-author 1

María Belén Bachey belenbachey2020@gmail.com FME San Luis Juan Martin del Pueyrredon San Luis

Co-author 2

Florencia Butti florenciabutti@gmail.com FME La Plata Gran La Plata La Plata

Co-author 3

Florencia Cardone cardoneflorencia@gmail.com FME Mansilla Córdoba Cordoba

Co-author 4

María Elisa Armendariz mariafmcelisa@gmail.com FME Martinez Vicente Lopez Olivos

Co-author 5

Co-author 6

Co-author 7

Co-author 8

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Introduction

Protein-energy wasting syndrome is a determining factor of morbidity and mortality in end stage renal disease (ESRD). Most adults undergoing hemodialysis (HD) show some evidence of muscle wasting. Clinical and experimental studies have suggested that secondary hyperparathyroidism (SHPT) plays a vital role in increasing energy expenditure and protein catabolism in patients with ESRD. Considering these effects, our study aims to investigate if the prevalence of muscle atrophy (MA) is higher in HD patients with SHPT.

Methods

Multicenter study with comparative, observational, cross-sectional prospective design. Chronic in-center prevalent HD patients over 18 years of age from Fresenius Medical Care clinics in Argentina were studied during 2023. Data were obtained from the European Clinical Database (EuCliD®). Multifrequency bioimpedance (Body Composition Monitor Fresenius Medical Care®) measurements were performed. Muscle mass depletion was defined as a lean tissue index LTI <10th percentile. iPTH values up to 599 pg/ml were considered normal. To determine the difference between prevalences, the chi-square test was estimated, where p<0.05 was considered significant.

Results

The sample consisted of 6358 patients, 57.3% male, with a mean age of 58 years and a time on HD of 6.7 years. The prevalence of STPH was 33.9% (N: 2153) and the prevalence of muscle mass depletion in the total sample was 53.4% (N: 3393). In those with STPH, muscle mass depletion was observed in 54.2% of cases;, while in those with iPTH <599 pg/ml, it was 52.9% with a p value of 0.338, so there was no statistically significant difference.

Conclusions

These findings support the evidence of the high prevalence of MA in chronic HD patients. However, our findings do not support the hypothesis that the prevalence is greater in patients with SPTH. We conclude that although this study did not show/demonstrate an association between these two variables, it is essential to treat muscle wasting comprehensively, studying the multiplicity of factors inherent to chronic renal disease and dialysis treatment that lead to the high prevalence of PEW.

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