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Peritonitis is a major cause of discontinuing peritoneal dialysis modality among end-stage renal disease patients. Peritonitis is a well-known independent risk factor which can lead to technique failure and mortality in these patients. Hence, prompt intervention through identification of factors leading to Early-Onset peritonitis in peritoneal dialysis patients is crucial.
This is a retrospective cohort study of 552 newly initiated peritoneal dialysis patients in a tertiary renal center from January 1, 2019 to December 31, 2021. Patients were divided into Peritonitis-free (n=251), Early-onset peritonitis (<6 months, n=136) and Late-onset peritonitis (> 6 months, n=165) groups. Baseline clinical characteristics of each group was reviewed. Logistic regression was used to analyze risk factors associated with Early-onset peritonitis. Cox proportional hazard model was used to determine the effect of early-onset peritonitis on clinical outcomes.
Conclusions
Early-onset peritonitis was strongly associated with poor clinical outcomes. Hence, prompt identification of its risk factors and intervention can significantly reduce complications and reduce the number of patients discontinuing peritoneal dialysis as their modality.