METABOLIC COMPLICATIONS OF PERITONEAL DIALYSIS: PREDICTORS OF TECHNIQUE FAILURE IN SENEGALESE PATIENTS

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E-Poster

https://storage.unitedwebnetwork.com/files/1099/381f6a9d4f00d465223145f429ca0b93.pdf

Abstract Title

First Name *

Abdou

Last Name *

Niang

Co-author 1

Niakhaleen Keita kniakhaleen@gmail.com Dalal Jamm Hospital Nephrology Dakar

Co-author 2

Niokhor Diaw diawniokhor@gmail.com Aristide le Dantec Hospital Nephrology Dakar

Co-author 3

Moustapha Faye mfayeintaida@gmail.com Aristide le Dantec Hospital Nephrology Dakar

Co-author 4

Ahmed Tall Lemrabott ahmedtall35@hotmail.com Aristide le Dantec Hospital Nephrology Dakar

Co-author 5

Maria Faye mariafye@hotmail.com Aristide le Dantec Hospital Nephrology Dakar

Co-author 6

Bacary Ba babacary13@gmail.com Aristide le Dantec Hospital Nephrology Dakar

Co-author 7

Mansour Mbengue mansourmbengue92@gmail.com Dalal Jamm Hospital Nephrology Dakar

Co-author 8

El Hadji Fary Ka efaryka@yahoo.fr Aristide le Dantec Hospital Nephrology Dakar

Co-author 9

Abdou Niang niangabdou@yahoo.com Dalal Jamm Hospital Nephrology Dakar

Co-author 10

Co-author 11

Co-author 12

Co-author 13

Co-author 14

Co-author 15

Introduction

Technique survival is a core outcome for peritoneal dialysis, according to Standardized Outcomes in Nephrology-Peritoneal Dialysis. We aimed to identify causes and risk factors of technique failure in a large Senegalese cohort.

Methods

A retrospective cohort study was conducted between 2004 and 2020 in a first Senegalese PD unit in Dakar and death-censored technique failure was analyzed. Cox regression models were used to assess the association between potential risk factors and technique failure.

Results

A total of 62 / 232 patients (mean age: 45 years; sex ratio: 0,7) experienced technique failure during follow-up. Technique failure rates at 1, 2, 3 and 5 years were 86.1%, 66.1%, 49.8% and 25.3%, respectively. In univariate analysis, male sex (HR: 0.57; 95% CI: 0.33 to 0.99; p = 0.048) was associated with lower rates of technique failure. Hypertension (HR: 1.19; 95% CI: 1.11 to 1.77; p = 0.028) and metabolic complications (HR: 1.31; 95% CI: 1.18 to 1.54; p < 0.001) were associated with higher rates of technique failure. In multivariate analysis, only metabolic complications (HR: 1.34; 95% CI: 1.19 to 1.60; p < 0.001) were associated with higher technique failure rates.

Conclusions

This study showed that metabolic complications are associated with PD technique failure, emphasizing the potential importance of metabolic complications managements in chronic PD.

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