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Anticoagulant related nephropathy (ARN) is a complication of anticoagulation therapy that results in acute kidney injury. Kidney biopsies from patients with ARN show mild glomerular disease with unmatched glomerular hemorrhage, red blood cell tubular casts and acute tubular necrosis. The clinical outcome of this condition is not well described.
The aim of the current study was to analyze 1-year clinical outcomes in patients with biopsy-proven ARN.
Renal pathology database at the OSUWMC was searched for kidney biopsies with ARN between 01.01.2009 and 04.30.2023. Demographic, clinical (renal function and mortality) and morphologic data were analyzed.
In total, 59 patients with ARN were identified, among those 48 patients had clinical follow up data. In 17 of those patients (35%), serum creatinine levels returned to baseline 1 year after the episode of ARN, whereas in 31 patients (65%), serum creatinine remained elevated for more than 30% from baseline or they died without kidney function recovery.
One year mortality was 35% in patients who did not recover from ARN, one patient in the recovery group died from malignancy with recovered kidney function. The only significant difference between these two groups was age, recovered patients were younger that non-recovered (55.1±14.3 yo. vs 66.2±11.5 yo). All other demographic, clinical and morphologic data were not statistically significant between these two groups.