The impact of pre-eclampsia on kidney function in a low resource setting in South Africa

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https://storage.unitedwebnetwork.com/files/1099/39a3f48fb0a5fefadbc632191c8c2817.pdf

Abstract Title

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Bianca

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Davidson

Co-author 1

Nicola Wearne nicola.wearne@uct.ac.za Groote Schuur Hospital, University of Cape Town Nephrology and Hypertension Cape Town

Co-author 2

Kate Bramham kate.bramham@kcl.ac.uk Kings College of London Nephrology and Hypertension London

Co-author 3

Erika Jones erika.jones@uct.ac.za Groote Schuur Hospital, University of Cape Town Nephrology and Hypertension Cape Town

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Introduction

Pre-eclampsia affects 10 – 15% of all pregnancies. High income countries have demonstrated significant, sustained hypertension, heart disease and kidney failure following pre-eclampsia. There is a dearth of data on long-term health sequelae following pre-eclampsia in low and low middle countries, which have the highest burden of pre-eclampsia globally. This study aimed to evaluate the impact of pre-eclampsia on kidney function and sustained hypertension.

Methods

This observational cohort study was performed at Groote Schuur Hospital, Cape Town, South Africa. Women with pre-eclampsia, were followed-up in the post-partum hypertension service (PPHS) from January 2020 – September 2023. Demographics, genetic variation, clinical parameters, patient and kidney survival were assessed.

Results

Conclusions

We found a third of women had AKI in pregnancy. Persistent hypertension was higher than the average prevalence, and the degree of sustained microalbuminuria was high. This highlights the importance of adequate management post-partum to preventative chronic kidney disease.

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