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The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are simple, inexpensive prognostic markers. Both had been used as marker of inflammation in CV and autoimmune diseases. Hence, this study was undertaken to assess the utility of NLR and PLR as markers of inflammation in hemodialysis and kidney transplant patients in a tertiary care center in Mexico.
A single center, retrospective study involving two groups: hemodialysis and kidney transplant in a tertiary Hospital in Guadalajara, Mexico. A consecutive sample was approached. Demographics, clinical and biochemical data, and inflammatory were assesses. Differences were compared using 2-sample t test for non-continuous variables and chi-square for categorical variables. Relationship between creatinine changes and inflammation markers were assessed using Pearson correlation coefficients. All statistical tests were performed using SPSS 28.0 and a P < 0.05 level of significance.
Hemodialysis and KT groups were compared with the means of the NLR and PLR, these differences being statistically significant (p<0.001). The correlation between INL and PLR scores was 0.830 with p < 0.001, and a relationship was found between these indexes both study groups with hemoglobin, albumin, CRP and ferritin. Comparison of NLR showed decrease for hemoglobin levels (HR = 3.675; p = 0.010) without increased on CRP (HR = 0.254; p < 0.001) and for the PRL showed increased in cholesterol values (HR = 1.363; p = 0.004) and CRP (β = 4.923; p < 0.001).
This study demonstrates NLR and PLR can be used as reliable markers of severity among kidney patients.