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Estimation of kidney function is crucial in the evaluation of living kidney donor candidates. Despite the multitude of glomerular filtration rate (GFR) formulas, no equation is universal. To evaluate for its presence, formulas based on serum creatinine are used, but up to 80% of these formulas underestimate the glomerular filtration rate (GFR) in donors. The aim of this work was to confirm the highest correlation of the GFR as measured with the use of DTPA-Tc99m with the GFR as estimated by means of the formula based on serum cystatin C (CKD-EPI creatinine–cystatin C) in healthy kidney donors.
This study enrolled 58 healthy living kidney donor candidates. In this observational, analytic, cross-sectional study, the GFR of kidney donors was determined before donation by means of DTPA gammagram and estimation with the use of conventional formulations and Cystatin C Equation.
Of 58 donors, male representation was 47% while female representation was 52% . Correlation with the GFR as measured by means of DTPA gammagram was better with the use of eGFRcr (0.369; P = .004) than eGFRcys (0.290; P .22) . An overestimation of glomerular filtration rate of up to 40% with eGFRcys compared to eGFRcr of 17% was observed with respect to DTPA gammagram.
To estimate the glomerular filtration rate in living kidney donor candidates, Its preferred used renal gammagram instead of the usual formulas due to the risk of overestimating kidney function. In this study , estimate the GFR by equations based on creatinine have a more correlation with DTPA-Tc99m gammagram.