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Results. The study group consisted
of 55.0% boys and 45.0% girls aged 6 months to 17 years (mean age 9.8±3.7
years, Me-10.5 years, σ-3.8). Family history of
urinary system diseases was aggravated in half of the children (45.5%). The
mean age of disease debut was 5±0.6 years (min-6 months, max-10.3, Me-4.8y, σ-2.3y); mean disease duration was 4.44±0.6 years
(Me-4.5y, σ-2.9y).
At the time of
nephrobiopsy, edema was noted in 35% of children; hypertension in 15%; mean
proteinuria was 2.5±3.2 g/day; proteinemia 49.8±16.6 g/L, albuminemia
29.1±11.4 g/L, and blood cholesterol 7.1±3.2 mmol/L. Herpetic infection
persisted in 28.4% of cases. At the time of examination, the majority of
children (75.0%) had stage I chronic kidney disease, 20.0% had stage III chronic
kidney disease, and one child had stage V chronic kidney disease. In the
debut of the disease, no effect of steroid therapy at a dose of 2 mg/kg per
day for 6 weeks was noted in 100% of children. According to light-optical,
immunofluorescence, electron-microscopic studies of nephrobiopsy specimens,
diffuse non-immunocomplex podocytopathy with splitting of small outgrowths of
podocytes (from 60% to 100%) prevailed (80.0%); in two children - with the
formation of focal segmental glomerulosclerosis. Diffuse membranous
nephropathy (5%), complement-associated renal tissue lesions from the group
of C3-glomerulopathies (5%); ultrastructural damage to the glomerular basal
membrane (GBM) pathognomonic for collagen type IV pathology (5%) were
detected in single cases. Subglobular glomerulosclerosis (100%); disorder of
anatomical histoarchitectonics and differentiation of the tubule apparatus
with sharp pseudocystic dilatation of the lumen; total acute damage of the
tubule epithelium were verified in a six-month-old girl.
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