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Chronic kidney disease (CKD) is associated with an increase in cardiovascular mortality and is a risk multiplier in patients with diabetes (DM). Unlike other chronic non-communicable diseases (NCDs) with early identification and intervention strategies, there is no consensus on the development of actions that contribute to the prevention of CKD. Physical exercise (PE) is capable of reducing the progression of chronic diseases. Objective: To evaluate the effect of physical exercise on renal function in animals with DM and CKD subjected to iodinated contrast (IC) nephrotoxicity.
Male Wistar rats, 250g-300g, in groups: Citrate (CT); CT+E; DM; DM+E; DM+CI; DM+CI+E; sham; Sham+E; CKD; CKD+E; CKD+IC; CKD+CI+E. E consisted of swimming, 60 min/day, 5 days/week. Markers of renal function, renal hemodynamics, oxidative profile and renal histology were used.
Physical exercise attenuated the deterioration of renal function by 25-30% in the exercised groups and reduced oxidative stress when compared to sedentary groups. There was a 40-50% reduction in renal tubulointerstitial injury in animals subjected to E.
Physical exercise confirmed a renoprotective effect in DM and CKD animals subjected to nephrotoxic insult with IC with improvement in hemodynamics, oxidative profile and histology.