Propolis supplementation decreases oxLDL plasma levels in patients undergoing hemodialysis

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https://storage.unitedwebnetwork.com/files/1099/0a0104092adfd8acb9942adbbaf3f549.pdf

Abstract Title

First Name *

Livia

Last Name *

Alvarenga

Co-author 1

Larissa Fonseca nutrilarissa.sfonseca@gmail.com Fluminense Federal University Graduate Program in Medical Sciences Niterói

Co-author 2

Livia Alvarenga liviaalvarenga92@gmail.com Federal University of Rio de Janeiro Graduate Program in Biological Sciences – Physiology Rio de Janeiro

Co-author 3

Ludmila Cardozo ludmila.cardozo@gmail.com Fluminense Federal University Graduate Program in Nutrition Sciences Niterói

Co-author 4

Marcia Ribeiro ribeiromarcia.trabalhos@gmail.com Federal University of Rio de Janeiro Graduate Program in Biological Sciences – Physiology Rio de Janeiro

Co-author 5

Andresa A. Berretta andresa.berretta@apisflora.com.br Apis Flora Indl. Coml. Ltda. Research, Development & Innovation Department Ribeirão Preto

Co-author 6

Denise Mafra dmafra30@gmail.com Federal University of Rio de Janeiro Graduate Program in Biological Sciences – Physiology Rio de Janeiro

Co-author 7

Co-author 8

Co-author 9

Co-author 10

Co-author 11

Co-author 12

Co-author 13

Co-author 14

Co-author 15

Introduction

Oxidative stress plays a central role in atherogenesis, a common chronic inflammatory disease in patients with chronic kidney disease (CKD), characterised by the accumulation of fatty substances into the vascular subintimal layer, mainly the modified LDL under the presence of reactive oxygen species (ROS) forming oxidised LDL (oxLDL), which participates in the development of atherosclerosis along with inflammation. Nutritional strategies have been proposed as an adjuvant therapeutic to modulate oxidative stress based on the role of bioactive compounds on scavenger ROS. In this scenario, propolis extract is a promising alternative to modulate oxidative stress in patients with CKD. Thus, this study aimed to evaluate the effects of green propolis extract on inflammatory and oxidative stress markers in patients with CKD on HD.

Methods

This is a longitudinal, double-blind, placebo-controlled trial in which patients were randomly assigned to one of two groups. The first group received propolis (consisting of 4 capsules, each containing 100 mg/day of concentrated and standardized dry EPP-AF® green propolis extract), while the second group received a placebo (consisting of 4 capsules, each containing 100 mg/day of microcrystalline cellulose, magnesium stearate, and colloidal silicon dioxide) for a duration of two months. The plasma levels of oxLDL were analysed by enzyme immunoabsorption assay (ELISA, R&D Systems, Minneapolis, MN, USA).

Results

Twenty-four patients concluded the study: 9 patients in the propolis group (50.0 ± 7.0 years, 4 men, 22.6 ± 6.9 kg/m²) and 15 in the placebo group (46.0 ± 13.5 years, 5 men, 26.1 ± 5.8 kg/m²). After supplementation, oxLDL plasma levels decreased significantly in the propolis group [from 946 (766-1212) pg/mL to 824 (700-1011) pg/mL, p-value=0,02]. In the placebo group, there was no statistically significant difference before and after the intervention [from 1073 (805-1331) pg/mL to 825 (695-1078) pg/mL, p-value=0.13].

Conclusions

The obtained data revealed that the two-month intervention with propolis significantly reduced the oxLDL plasma levels in patients with CKD undergoing hemodialysis.

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