BURDEN OF TUERCULOSIS IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING MAINTAINACE HEMODIALYISIS TREATMENT IN ADDIS ABABA, ETHIOPIA: A CROSS-SECTIONAL STUDY

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BURDEN OF TUERCULOSIS IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING MAINTAINACE HEMODIALYISIS TREATMENT IN ADDIS ABABA, ETHIOPIA: A CROSS-SECTIONAL STUDY
Wubshet Jote
Tolossa
Eyob Beyene Deyasu eyobebu@gmil.com Addis Ababa University Internal Medicine Addis Ababa
Addisu Melke Ejigu addisbirrgez@yahoo.com Addis Ababa University Internal Medicine Addis Ababa
Wondwosen Amogne Degu wonamogne@yahoo.com Addis Ababa University Internal Medicine Addis Ababa
 
 
 
 
 
 
 
 
 
 
 
 

Patients with End-stage renal disease (ESRD) are at a higher risk of developing Tuberculosis (TB) due to immunosuppression along with socioeconomic, demographic, and comorbidities. Despite the high burden of Tuberculosis in developing countries, there is a scarcity of data regarding the burden of TB in ESRD in Ethiopia. The objective of this study is to assess the burden of TB in End stage renal patients receiving hemodialysis in Addis Ababa, Ethiopia.

A cross-sectional study was conducted on the Burden of Tuberculosis in stage 5 chronic kidney disease patients undergoing maintenance hemodialysis therapy in governmental and non-governmental dialysis centers in Addis Ababa, Ethiopia from August 2022 to October 2022 G.C. Patients with a baseline diagnosis of ESRD on hemodialysis above 18 years of age were included in the study. Patients were recruited during their dialysis visit using a convenient sampling method and consent was obtained from all participants. A total of 263 participants were included in this study. The diagnosis of ESRD and TB was defined using KDGIO and WHO guidelines. Data were collected through patient interviews and reviewing the patient’s electronic medical records. The Collected Data was analyzed using SPSS version 26.0.

Our study found a history of TB diagnosis in 27% of study participants. Among the study participants who were diagnosed with TB, 16.9% had active TB. Pulmonary tuberculosis was diagnosed in two-thirds of TB patients and about a third had EPTB, TB lymphadenitis was the commonest followed by pleural TB.  Imaging evidence was used to make a diagnosis of TB in one-third of patients followed by FNAC (26.6%) and Pleural fluid analysis (26.6%). More than half (54.7%) of TB diagnosis was made after the initiation of hemodialysis. Having a contact history with a known TB patient, presence of HIV infection, and duration on dialysis for more than one year were associated with increased prevalence of TB among CKD patients.

Because of its atypical presentation and overlapping uremic symptoms of uremic, physicians should maintain a high degree of suspicion to consider TB among ESRD patients. Early identification and treatment of TB among ESRD patients is important in decreasing morbidity and mortality among these patients and in decreasing the transmission of TB among patients who undergo dialysis in the same center. TB preventive therapy should also be considered for this group of patients    

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