Industry Symposium 31

Session Title: Complement-Mediated Kidney Disease: From Mechanisms to Therapies
Organized by: eleva GmbH

Session Description:
Complement-mediated inflammatory kidney diseases - including C3 glomerulopathy, immune complex–mediated membranoproliferative glomerulonephritis, and IgA nephropathy - are driven by dysregulation of the alternative pathway of complement. While diagnosis traditionally relies on kidney biopsy findings, these diseases exhibit substantial pathological heterogeneity. Therefore, extended diagnostic testing - including quantification of complement activation products and split fragments, identification of autoimmune drivers such as C3 nephritic factors, and targeted genetic analyses - is essential to enhance diagnostic accuracy and enable precision classification.

Learning Objectives:
- Define the pathogenic role of complement in inflammatory glomerular diseases.
- Provide an overview of current modern diagnostic approaches, including pathology evaluation, complement analytics, genetic testing, and autoimmune diagnostics.
- Integrate these diagnostic modalities into clinical decision-making and everyday-practice for the benefit of patients.
- Present mechanistic rationales for therapeutic intervention at multiple levels of the complement cascade.
- Summarize the evolving landscape of complement-targeted therapeutics in inflammatory kidney diseases, including next-generation treatment strategies.