Introduction:
Protein energy wasting (PEW) is a condition where the body's excess catabolism reduces protein and energy reserves. It is associated with increased mortality and morbidity as well as decreased quality of life from Chronic Kidney Disease (CKD) patients. Inflammation is a key factor in PEW incidence. However, research on marker factors like vitamin D and high sensitivity C-Reactive Protein (hs-CRP) to predict PEW in non-dialysis stage 3-5 CKD patients is limited.
Methods:
This study is an analytical observational study with a cross-sectional design. This study was conducted on 40 subjects through initial screening, laboratory examination, body mass index (BMI) examination, upper arm circumference measurement, and food intake recording. PEW diagnosis is established by the International Society of Renal Nutrition and Metabolism (ISRNM). A comparative analysis was performed with the Mann-Whitney test due to abnormal data distribution.
Results:
Median vitamin D levels in non-dialysis stage 3-5 CKD patients with PEW were significantly lower compared to stage 3-5 non-dialysis CKD patients without PEW (18.7 vs 30 ng/ml, p=0.002). Median hs-CRP levels in stage 3-5 non-dialysis CKD patients with PEW were significantly higher compared to stage 3-5 non-dialysis CKD patients without PEW (14.05 vs 2.45 ng/ml, p=0.016).
Conclusions:
Vitamin D level in stage 3-5 non-dialysis CKD patients with PEW was significantly lower compared to stage 3-5 non-dialysis CKD patients without PEW. High Sensitivity C-Reactive Protein in CKD patients with PEW was significantly higher than CKD patients without PEW.
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.