Introduction:
Non-tunneled central venous catheter remains the preferred vascular access at hemodialysis initiation in developing countries despite a high burden of infection complications. The goal of this study was to determine the burden,risk factors and microbiological spectrum of catheter-related bloodstream infections at tertiary care center in Ethiopia.
Methods:
A retrospective cross-sectional study design was applied among patients who underwent central venous catheter insertion for hemodialysis from January 2017 to June 2022 with no naive arteriovenous fistula staying more than 48 hours. Data was collected from the patients registration book,patients charts and microbiology registry and analysed using SPSS 21. Binary logistic regression was applied to assess the relationship between the independent and outcome variables. P value less than 0.05 with AOR and 95%CI were used as statically significant variable.
Results:
In this study, 353 patients were included. The mean age was 39+/_17.9 years and the average duration catheter stay was 58+/_95 days. A hundred thirty five (38.2%) catheter-related bloodstream infections was documented with an incidence rate of 7.74 episode per 1000 catheter days. The causative microorganism were predominantly gram-negatives (57.6%). Duration of a catheter(AOR:0.3 p value <0 001), previous central venous catheter insertion (AOR:11.9 p value <0.001), high white blood cells (AOR:0.31 p value <0.001),Rural residence (AOR:1.92 p value <0.05), and low Hemoglobin level (AOR:2.78 p value <0.05) were independently associated with catheter-related bloodstream infections.
Conclusions:
In conclusion, the incidence of catheter-related bloodstream infections among patients on hemodialysis was high with gram-negative predominance. Early fistula must be created to reduce the duration of temporary vascular access.
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.