KIDNEY TRANSPLANTATION FROM DECEASED DONORS AT CHO RAY HOSPITAL, VIETNAM

Introduction:

Kidney transplantation (KT) from deceased donors (DD) has emerged as a global solution to address the limited availability of organs from living donors. While international studies have demonstrated encouraging outcomes, data from our country, particularly from Cho Ray Hospital, remains limited. This study aims to evaluate the results of kidney transplantation from deceased donors at Cho Ray Hospital.

Methods:

This descriptive case series study included all kidney transplant recipients (KTR) from deceased donors who were followed up at Cho Ray Hospital between April 2008 and September 2024. The donors were categorized into brain-dead donors (DBD) and circulatory-dead donors (DCD). Clinical outcomes, including graft and patient survival rates, delayed graft function (DGF), serum creatinine (Scr) levels, and estimated glomerular filtration rates (eGFR), were analyzed.

Results:

A total of 32 DBD (62 KTRs) and 5 DCD (10 KTRs) were included. The median age of DBD and DCD donors was 36.5 and 37 years, respectively, while the median age of KTRs was 36 years for DBD and 44.5 years for DCD. Median waiting times for transplantation were 41 and 57 months, respectively. Median cold ischemia times were 5.4 hours (DBD) and 10.5 hours (DCD), with median second warm ischemia times of 39 minutes (DBD) and 41.5 minutes (DCD). The median warm ischemia time for DCD was 11 minutes. DGF occurred in 17.4% of DBD KTRs and 75% of DCD KTRs. Median Scr at discharge and 12 months was 1.2 mg% and 2.8 mg% for DBD, and 1.2 mg% and 2 mg% for DCD. Median eGFR at discharge and 12 months was 68.5 and 31.7 ml/min/1.73 m² for DBD, and 69.5 and 42.5 ml/min/1.73 m² for DCD. Non-dead censored graft survival rates at 1, 5, and 10 years for DBD were 100%, 91.1%, and 69.5%, while patient survival rates were 98.4%, 96.3%, and 75%. For DCD, non-dead censored graft survival rates at 1, 5, and 8 years were 100%, 83.3%, and 62.5%, with patient survival rates remaining at 75% across all intervals. Deceased donors contributed 6.8% to the kidney donor pool at Cho Ray Hospital.

Conclusions:

Kidney transplantation from brain-dead donors (DBD) at Cho Ray Hospital demonstrates favorable outcomes, while transplantation from circulatory-dead donors (DCD) shows relatively promising but more variable results. Further studies with larger sample sizes are necessary to expand the deceased donor pool and enhance patient access to transplantation.

I have no potential conflict of interest to disclose.

I did not use generative AI and AI-assisted technologies in the writing process.