Introduction:
Parents and spouses constitute 70% of organ donors in India. ABO-incompatible kidney transplants from spousal donors carry a very high immunological risk due to both HLA and ABO incompatibility. This study was designed to compare the outcomes of ABO-incompatible transplant recipients between parental donors (PDs) and spousal donors (SDs).
Methods:
This retrospective study was conducted at a single-center tertiary care hospital, where 516 living donor renal transplants were performed between October 2019 and February 2024. Adults aged 18 years or older who underwent ABO-incompatible renal transplantation from spousal or parental donors were included in the study, with a minimum follow-up period of 6 months.
Results:
Our study included 37 patients with parental donors and 35 patients with spousal donors. The mean recipient age in the parental donors group was 29.4 ± 7.6 years, and in the spousal donors group, it was 51.2 ± 6.4 years (p<0.001). The median follow-up period was 25 months. The death-censored graft survival rates at 1 year were 97% for recipients of parental donors and 94.2% for recipients of spousal donors. At 2 years, these rates were 94.5% and 94.2%, respectively, and at 3 years, they were 94.5% and 91.3%, respectively. The infection rates in the parental donors and spousal donors groups were 10% and 28%, respectively (p=0.108). The rates of acute rejection (biopsy-proven and clinically treated) were 24.3% in the parental donors group and 20% in the spousal donors group. There was a single death at 19 months post-transplant due to malignant colon carcinoma.
Conclusions:
The death-censored graft survival, patient survival, acute rejection rates, and infection rates did not differ significantly between transplant recipients of spousal donors and those of parental donors.
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.