Introduction:
Renal transplantation offers the best treatment for a child with End Stage Renal Disease (ESRD). Quality of life, patient survival , growth and cognition are superior in children who have undergone transplantation compared to those on dialysis. The aim of the study was to evaluate the clinical outcomes of pediatric renal transplants done at our institution over the study period
Methods:
The study was conducted in patients with ESRD below 18 years of age, who underwent renal transplantation atour institution. Those with multi organ transplantation and those who were lost to follow up were excluded from the study. Data from charts and medical records of all patients below 18 years of age who received a kidney transplant from November 2015 to June 2024 were collected. Data included demographics, anthropometry, pre and post- transplant requirement of anti-hypertensive medications, etiology of ESRD, dialysis modality, donor details, the incidence of acute or chronic rejection , patient and graft survival
Results:
46 children were included in the study, of which 59% were males. There were 17 children below 10 years of age, and 29 between 11 and 18 years . The mean follow up period was 55 months (range 2- 104months ) Six children weighed less than 10 kgs at the time of surgery and 10 children weighed between 10- 20 kgs . Congenital anomaly of kidney and urinary tract ( 48 %) and chronic glomerulonephritis( 34 % ) were the common native kidney diseases that led to ESRD. Mother was the donor in 66% cases, others being fathers ,grandparents , brothers. All children received triple immunosuppression with Tacrolimus, Mycophenolate mofetil and Prednisolone. Induction with Basiliximab was given for 24 children and ATG was given for 7 children. 6 children had graft loss during the follow up period and back on dialysis: 3 graft loss occured with in one year and other 3 between three and five years after surgery: of these, 2 adolescent children lost the graft due to non compliance to medicines and other 4 had antibody mediated rejection .Graft survival was 94 % at 1 years and 3 years where as 86% at the end of five years and patient survival was 98% at 1 year, 3 years and 5 years
Conclusions:
Congenital anomaly of kidney and urinary tract and glomerulonephritis are the most common causes for ESRD in children. The outcomes of renal transplantation in children is very good. Graft survival was 94 % at 1 years and 3 years where as 86% at the end of five years and patient survival was 98% at 1 year, 3 years and 5 years
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.