Introduction:
Children with End-Stage Kidney Disease (ESKD) and especially those on dialysis are burdened with a high inflammatory load leading to endothelial dysfunction which results in high cardiovascular morbidity and mortality. There are very few studies comparing inflammatory markers in children on peritoneal dialysis (PD) and hemodialysis (HD).The primary objective was to measure levels of Fibroblast Growth Factor 23 (FGF23), high sensitivity C-Reactive Protein (hsCRP) and Interleukin-6 (IL-6) in children with ESKD undergoing maintenance dialysis and compare levels in those on HD and PD.
Methods:
This was a cross sectional hospital based study involving children 1-18 years of age with ESKD on maintenance HD or PD for at least 3 months at our hospital. The inflammatory marker levels were measured and compared between the two groups as well as correlated with clinical and laboratory parameters.
Results:
A total of 16 children were included in the study (10 on PD and 6 on HD). All the patients on PD were on continuous ambulatory PD. The mean hsCRP was 3.20±0.69 mg/L in all dialysis patients, 3.14±0.59 mg/L in HD group and 3.28±0.87 mg/L (p=0.515) in PD group. The mean IL-6 was 1.69±0.46 pg/ml in all dialysis patients, 1.81±0.37 pg/ml in HD group and 1.50±0.56 pg/ml in PD group (p=0.913). The mean FGF 23 was 811.54±128.6 ng/ml in all dialysis patients, 821.7±137.9ng/ml in HD group and 794.6±121.6 ng/ml in PD group (p=0.233). IL-6 showed positive correlation with dialysis vintage (R=0.509, p=0.044) and FGF23 levels (R=0.547, p=0.028).
Conclusions:
hsCRP and FGF23 were increased in children on dialysis. There was no difference in inflammatory markers in children on HD versus PD. IL-6 levels positively correlated with dialysis vintage and FGF23 levels.
I have potential conflict of interest to disclose.
Study done under grant from state board of medical research, Kerala
I did not use generative AI and AI-assisted technologies in the writing process.