Introduction:
The use of tunneled dialysis catheters to deliver hemodialysis treatment may be associated with major problems. For this reason their use should be minimized as much as possible. Infection is the most serious of these problems. This complication causes very significant morbidity and mortality and has emerged as the primary barrier to long-term catheter use. Bacteremia is the most serious type of infection associated with catheter use. It can result in metastatic infection and even lead to death of the patient. Prophylaxis is important to decrease the risk of infection. The use of an antibiotic ointment at the exit site until it has healed and the long-term use of a dressing to cover the exit site are effective in decreasing the incidence of exit-site infection.
Aim -To describe SQ53, a novel, patented biocidal antimicrobial gel with focus on bacterial attachment and biofilm formation and prevention of Catheter-related blood stream infection in End stage Renal disease patients undergoing tunneled cuffed Catheter insertions.
Methods:
It was a single centre study.patients were included in this study on compassionate grounds from March 2024 to date. SQ53 is A novel, patented, biocidal, antimicrobial solution that can be made in different forms e.g. as a gel,solution,wipes.It has been tested against a wide range of bacteria, viruses, spores and fungal pathogens.Extensive laboratory testing has demonstrated the effectiveness of SQ53 gel lasting over a 24 hour plus time period. In addition, it includes no development of VNBC populations or evidence of resistance to the active compounds.SQ53 gel was used in appropriately identified patients who underwent Tunneled cuffed catheter insertion.SQ 53 gel was used at venous puncture site and tunnelled catheter exit site at the end of the procedure.A transparent dressing was done after the apllication of gel.The antibiotic gel was used at the exit site until it has healed.Data collected included demographics of patients, etiology for requiring a TCC, Incidence of catheter related blood stream infections, type of infection, morbidity and mortality.
Results:
From March to date, 118 patients who underwent tunneled cuffed catheters were included in the study. Of the 118 patients, 10 were in the pediatric age group (less than 18 years).Rest were adults.70 were male patients and 48 were female patients.The common causes of ESRD are diabetes( 45), CGN 20, chronic tubulo interstitial nephritis 25, and others 10 percent..Out of 118 patients only 3 patients had documented catheter infections.
Conclusions:
The use of SQ53, a novel, patented biocide antimicrobial gel as an adjunct to standard insertion and cleaning regimens for tunneled cuffed catheters in India, significantly dropped the incidence of CLABSIs.This study has demonstrated that a single, easy to use intervention with sterile SQ53 gel has brought down the incidence of CLASBIs dramatically in our practice.
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.