Introduction:
Estimating a precise level of overhydration (OH) in patients with end-stage kidney disease (ESKD) undergoing maintenance hemodialysis (MHD) and continuous ambulatory peritoneal dialysis (CAPD) remains a challenging issue. In this research, we compared the accuracy of OH measurement by standard bioelectrical impedance analysis (BIA) device with the new portable and wearable BIA device (InbioZ).
Methods:
We conducted a cross-sectional study in a dialysis center located in Fatmawati Hospital to adult patients on MHD and CAPD. BIA measurements were performed before the HD session for MHD groups; and before vs after draining out the dialysate fluid from peritoneal cavity for those in CAPD group. Measurements were performed using the Fresenius GENIUS 90 BCM as the gold standard and InbioZ dialysis as a comparative measurement tool. We compared the overhydration result in both devices.
Results:
There were 70 subjects collected in this study with the mean age 50.4±15.2 years-old. Subjects were consisting of 55 patients in MHD group and 15 patients in CAPD group. Most of the subjects (92,9%) were non-severely overhydrated (defined as OH to Extracellular Water [ECW] ratio <15%) category. Mean OH level for overall subjects was 2.7± 1.8 L. There were no statistically significant differences between groups according to their comorbidities, dialysis access type, blood pressure, and laboratory parameters. The InbioZ device showed no statistically significant difference of its measured OH level compared to the standard BIA device for all subjects (p=0.605), and also subgroup analysis based on renal replacement therapy modality showed no difference of OH level measurement, both in MHD group (p=0.617) and CAPD group (p=0.133). Within CAPD groups, there is no difference in OH result when the examination done with the dialysate or without dialysate in the peritoneum cavity (p=0.320, 0.256 respectively).
Conclusions:
The InbioZ device can be an alternative assessment method to determine OH level in patients undergoing MHD or CAPD, as compared to standard BIA device.
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.