Introduction:
We often come across dehydration induced acut kidney injury (AKI) and rhabdomyolysis induced AKI in fitness enthusiasts and athletes, but we report a rare genetic syndrome associated with idiopathic renal hypouricemia precipitating exercise induced AKI (EIAKI).
Methods:
27 year old gentleman with vomiting, abdominal pain and an increased serum creatinine level of 6 mg/dl and a normal cpk with no rbcs, casts in the urine analysis. His uric acid was abnormally low - 1.3 mg/dl. He also revealed a similar history about 9 years back when the uric acid was found to be 0.5 mg/dl. Suspecting hypouricemia to be the trigger for EIAKI. genetic analysis was sent.
Results:
Genetic analysis revealed compound heterozygous mutation in SLC2A9 which codes for uric acid transportation channels in renal tubules this establishing our diagnosis of idiopathic renal hypouricemia precipitating EIAKI.
Conclusions:
Patient was discharged with a creatinine of 1.11mg/dl. He was advised to be well hydrated before exercise and sports events. We conclude that EIAKI is not always due to rhabdomyolysis Or secondary to dehydration. Hypouricemia induced EIAKI should be kept on the horizon when dealing with EIAKI.
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.