Introduction:
IgA nephropathy (IgAN), also known as Berger's disease, is the most common primary glomerulonephritis worldwide, characterized by the deposition of IgA antibodies in the glomerular mesangium. Although typically a sporadic disease, familial forms of IgA Nephropathy have been increasingly recognized. To date, more than 90 families with multiple members with IgA nephropathy have been reported. Immunogenetic studies does not conclusively indicate that HLA is involved in the pathogenesis of IgA nephropathy. The specific mode of inheritance of familial IgA nephropathy is difficult to establish with certainty. Familial IgA Nephropathy presents a unique opportunity to explore the genetic and environmental factors contributing to disease pathogenesis.
Methods:
Results:
We report a case of 40-year-old male who was diagnosed to have IgA nephropathy at the age of 25 years with a strong family history of IgA nephropathy in 3 of the other family members including his mother, younger brother and maternal uncle, all attaining end stage renal disease at different age group. This case report highlights the clinical presentations, diagnostic findings, and the potential genetic implications.
Conclusions:
Through this case, we aim to further understand the familial occurrence of IgA Nephropathy and discuss the challenges and implications of managing this hereditary form of the disease.
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.