Introduction:
Background: CD24 is a protein, which is induced during tissue damage and is not expressed in matured renal tissue. We have shown that, during AKI, upregulation of CD24 promotes renal inflammation and worsen renal function. In the current studies, we aim to explore a possible role for CD24 in chronic renal failure (CRF) as well.
Methods:
CRF was induced by a 0.2% adenine diet administered to WT and CD24-/- mice for 4 weeks. Renal function tests, histology, immunohistochemistry, western blot analysis, and ELISA were performed to assess the severity of renal damage and explore the mechanism
Results:
CRF induced CD24 in the distal tubular epithelial cells. Compared to WT mice, CRF CD24-/- mice exhibited an attenuated decrease in renal function, less albuminuria, and decreased histological injury. The augmentation of TGFβ and αSMAD expression (a pro-fibrotic proteins) induced by CRF was significantly reduced in CRF CD24-/- compared to CRF WT animals. In CRF CD24-/- animals the increase in serum FGF23, renal FGF23R and the decrease in renal Klotho was significantly attenuated compared to WT CRF mice.
Conclusions:
Renal CD24 induction in CRF aggravates the severity of the disease. These findings are associated with attenuation of CRF induced decrease in renal klotho and increase in serum FGF23 and renal FGF23 receptor.
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.