MEAN PLATELET VOLUME AS POTENTIAL BIOMARKER FOR PROTEINURIA IN PATIENTS WITH TYPE II DIABETES MELLITUS: A CROSS-SECTIONAL STUDY FROM A TERTIARY HEALTH CARE CENTER

Introduction:

Type 2 Diabetes Mellitus (T2DM) is a chronic condition characterized by insulin resistance and high blood glucose levels. Managing T2DM requires monitoring various biomarkers to assess the risk of complications and the effectiveness of treatment strategies. This study focused on the Mean Platelet Volume (MPV) as a potential marker for protein urea and subsequent renal impairment in T2DM patients. MPV is an indicator of platelet activation, which plays a role in inflammatory processes associated with diabetes complications. In this study, we aimed to explore the relationship between MPV and the urine protein-to-creatinine ratio (UPCR) in patients with Type II Diabetes Mellitus and to assess the relationship between MPV and other biochemical parameters.

Methods:

This cross-sectional study was conducted over six months at a tertiary health care centre, and patients with T2DM, aged 18-65 years were included. Patients with a history of any other chronic disease, such as cancer or chronic liver disease, and those on medications that affect platelet function, such as aspirin or clopidogrel. Comprehensive demographic and clinical data, along with laboratory investigations were analyzed. Statistical analysis using Spearman's correlation was conducted to assess the association between the MPV and these parameters.

Results:

A total of 92 eligible patients were analyzed. The baseline characteristics of the patients are summarized in Table 1. The mean age of the patients was 56.01 ± 13.67 years, with 55.5% being male. The mean serum creatinine level was 1.78 ± 1.29 mg/dL, whereas the Mean Platelet Volume (MPV) was 9.58 ± 1.19 fL.

The study found a significant positive correlation between MPV and urine protein creatinine ratio (rho = 0.624, p < 0.001), suggesting that higher MPV values are associated with increased proteinuria. This suggest as MPV increases, the level of proteinuria in patients with type 2 T2DM also increases. These suggest higher MPV may serve as a marker for worsening renal function in patients with diabetes, as proteinuria is a key indicator of diabetic nephropathy, a common T2DM complication. Monitoring the MPV could provide additional insights into renal health. Regular monitoring of MPV could facilitate the early detection and management of renal complications, slow the progression of diabetic nephropathy, and improve patient outcomes.

The study also found a significant positive correlation between MPV and urine protein creatinine ratio (rho = 0.624, p < 0.001), suggesting that higher MPV values are associated with increased proteinuria and, by extension, renal impairment in T2DM patients. This indicates that MPV could be a useful marker for early detection of kidney issues in these patients. (Figure 1) Additionally, a moderate positive correlation was observed between MPV and HbA1c level (rho = 0.46, p < 0.001). This finding suggests that MPV may also reflect glycemic control, with higher MPV values being associated with poorer glucose regulation. The correlation of MPV with the other parameters is shown in Table 2.

Conclusions:

The study concluded that MPV has significant potential as a biomarker for assessing both renal impairment and glycemic control in patients with T2DM. The strong correlation between MPV and urine protein creatinine ratio underscores its utility in identifying patients at risk for diabetic nephropathy.

I have no potential conflict of interest to disclose.

I used generative AI and AI-assisted technologies in the writing process.
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