Introduction:
The interplay between uric acid and chronic kidney disease(CKD) has been under contention for several years, however, the prevalence of Hyperuricemia in chronic kidney disease patients been found to be increased in comparison with people without any renal impairment Hyperuricemia is defined as serum uric acid >7mg/dl in males and > 6mg/dl in females. Uric acid levels has been found to be a predictor of CKD and metabolic diseases. The high prevalence of hyperuricemia in CKD has been attributed to decrease urinary clearance of uric acid, however studies suggest that it has causative and predictive functions in CKD and cardiovascular events. The major players and risk factors in CKD(Diabetes and hypertension)have been linked to elevated uric acid levels.
Methods:
An observational cross sectional study was carried out among 160 CKD patients at a tertiary hospital in south east Nigeria. Consecutive patients with CKD presented at the renal clinics and wards of Enugu State University Teaching Hospital Parklane during the study period who met the criteria were recruited for the study. Age, sex, uric acid levels, blood pressure and diagnosis were documented. The data were entered in a spreadsheet and analysed using SPSS version 25. P values <0.05 were considered statistically significant
Results:
The prevalence of hyperuricemia among CKD patients was 29%. There was a male preponderance as 55% were males while 45% were female. Increasing age was noted as a contributing factor to hyperuricemia. 27.5% of the patients were hypertensive before the diagnosis of CKD was made. There was an increasing level of uric acid in patients with lower eGFR
Conclusions:
The prevalence of hyperuricaemia among CKD patients is high in this population and this is associated with male preponderance.
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.