Introduction:
IN CKD ND(CKD NOT ON DIALYSIS) IMPAIRED PULMONARY FUNCTIONS MAY BE DUE TO DIRECT EFFECT OF CIRCULATING UREMIC TOXINS OR MAY RESULT FROM FLUID OVERLOAD, ANEMIA IMMUNE SUPPRESION, EXTRAOSSEUS CALCIFICATION ,MALNURTRITION AND SO ON.PFT IS UNDERRATED INVESTIGATION TO ASSESS PULMONARY CHANGES IN CKD.
Methods:
A longitudnal prospective study comprising of 118 CKDND patients presenting at a tertiary care hospital, who met the inclusion( ckd nd ) and exclusion criteria (ckd 5D,ckd T, ILD,COPD ,recent (< 3 months) having pleural effusion or infection )were evaluated over 18 months. They underwent routine tests : cbc/lft/rft/cxray/urine routine and microscopy/ecg/2d echo/ usg whole abdomen and PFT. PFT and RFT were repeated at 9 months.
Results:
The mean baseline FEV₁ decreased from 2.87±0.49 litres to 2.58±0.51 litre, meaning FEV1 significantly declined after 9 months (<0.05).The mean baseline FVC was 3.55±0.53 litres and after 9 months were 3.36±0.57 litres ,FVC was also reduced significantly after 9 months (<0.05).
** indicates that the correlation is significant at 0.01 level
The mean baseline FEV₁/FVC was 80.66±2.72% and after 9 months was 76.52±3.26%. When we compared the mean values between two groups, FEV₁/FVC showed a significant decline after 9 months (<0.05).
Mean baseline eGFR declined from 38.01±14.23 mL/min to 34.29±12.45 mL/min after 9 months When we compared the mean values between two groups, the difference was found to be significant. It means eGFR was reduced significantly after 9 months (<0.05).Correlation of baseline eGFR with baseline PFT parameters showed positive correlation. We found that lower FEV₁/FVC ratio was associated with an increased risk of CKD during the mean follow-up.
Conclusions:
Pulmonary function tests showed significant deterioration with declining gfr, a casual association cannot be ruled out.
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.