Introduction:
Hematopoietic stem cell transplantation (HSCT) is being increasingly recommended for a variety of malignant and non-malignant conditions. Acute kidney injury (AKI) is a common complication with varied incidence ranging from 21-84%, can occur at different stages post HSCT and is associated with significant morbidity and mortality
Methods:
A retrospective cohort study from a tertiary care centre, including children under 18 years, who underwent HSCT from 2016 to 2023 was conducted. AKI was defined according to the Kidney Diseases: Improving Global Outcomes (KDIGO) criteria. Demographic, clinical and procedure related data were collected.
Results:
: A total of 40 children (boys 60%) with a mean age of 9.7 ± 5.47 years were included. Majority (37.5%) underwent HSCT for aplastic anaemia, followed by beta thalassemia major (15%), acute myeloid leukaemia (12.5%), acute lymphoid leukaemia (10%) and others (25%). During the first 3months post HSCT, 23 (57.5%) children had AKI, with 4 children having multiple episodes of AKI. From 3months to 12 months follow up, 17 (42.5%) children had AKI, with 3 children having multiple episodes of AKI, 2 children had transplant related thrombotic microangiopathy. Older children (HR 1.17, 1.0 -1.38) and CNI use (HR 1.9, 0.36, 3.02) was associated with higher risk of AKI after HSCT.
Conclusions:
Post HSCT children are at risk of AKI, hence a regular and consistent surveillance is required for prevention and early detection.
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.