Introduction:
Acute kidney injury (AKI) is a common complication of Lassa virus infection (LVI). Mortality associated with LVI and AKI might be increased by other factors besides the virus. The knowledge of these factors might be helpful to predict and manage AKI more efficiently.
Acute kidney injury is an established factor for mortality in Lassa fever. Laboratory and clinical prognosticators for Lassa fever-related acute kidney injury (LAKI) are not well studied. These identified prognosticators may be help in monitoring response to management.
Methods:
501 patients admitted and managed in the isolation unit of the Federal Medical Centre, Owo, Ondo State Nigeria between January 2019 and December 2024 were included in the study.
Medical records of Lassa fever-confirmed patients were extracted and analysed for their symptoms, symptom severity and outcome
Results:
The ages of the patients ranged from 4 days to 93 years with 50.5% female and 49.5% male. Of the patients who were admitted, 10% died while 88% were alive or discharged. Ninety percent of the patient that died had income level less than 200,000 naira per month, Fifty-one patients (10.2% of all admitted cases underwent renal replacement therapy. 30% of the admitted patients with RRT died. Creatinine, WBC, Urea and albumin are predictive od mortality
Conclusions:
Predictive biomarkers are needed to target critically ill patients for more aggressive interventions. Efforts towards meeting baseline functional needs as part of appropriate interventions, such as the implementation of best-bet supportive care would go a long way towards ensuring that a number of the identified risk factors of mortality are addressed
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.