PREDICTORS OF MORTALITY IN ESKD PATIENTS DIALYZING IN LAGOS STATE UNIVERSITY TEACHING HOSPITAL

7 Feb 2025 12 a.m. 12 a.m.

WCN25-AB-180, Poster Board= FRI-365

Introduction:

Mortality rate among patients with chronic kidney disease is higher compared to the general population and even worse in those with ESKD.

Kidney transplant is the preferred choice of renal replacement therapy however most patients in resource poor settings are not able to afford this and consequently remain on haemodialysis indefinitely which contributes to mortality rate in this subset of patients.

Therefore, there is a need to identify the predictors of mortality in ESKD patients on haemodialysis as identifying and addressing them could reduce mortality rate among these patients.

The aim of the study is to Identify sociodemographic, clinical and laboratory parameters that predict mortality among ESKD patients in LASUTH

Methods:

A descriptive retrospective study, involving 54 ESKD patients who have been having haemodialysis for at least 3 months at the dialysis unit in LASUTH.

Their sociodemographic, clinical and laboratory parameters were extracted from patients’ folders and analyzed using SPSS version 23. Association between categorical data was determined using chi-square test or Fischer exact test. Logistic regression was used to identify independent predictors of the mortality. All tests were carried out using a P-value of 0.05

Results:

The mean age of the subjects was 46.8±13.0 years, 64.8% were male, the average SBP 156.3±26.0mmhg while the mean DBP was 94.6±19.1mmhg with hypertension 22(40.7%) accounting for the most common aetiology . The mean duration on dialysis was 8.8±5.4 months. Twenty nine (53.7%) was moderately anaemic with a mean PCV of 23.7±3.8 %. The average level of serum albumin of the subject was 3.7±.5mg/dl. There was a significant association between serum albumin and the event of death with the odd death found to be 4.086(1.236 - 13.508. CI 95%) significantly higher among subject with low serum albumin. The odds of the event of death among subjects on dialysis for more than twelve months was 1.7(0.439 - 6.980. CI 95%) this association however not significant. The odds of the event of death among subjects who had dialysis more than once a week was 0.376(0.117 - 1.210. CI 95%) howbeit, this association was not significant. Subject with HIV was found to have the least mean survival time of 3.667months while subject with hypertension had the highest mean survival time of 13.318months. The overall mean survival time was 5.445 months Univariate Cox proportional hazard reveals no significant relationship between the aetiology of CKD and death among the subjects.

Demographic Characteristic of Subjects

Demographic Characteristic of Subjects(ctd)

Table 2: Clinical parameters of Subjects

Table 3: Laboratory parameters of Subjects

Table4: Association between demographic Characteristic and disease outcome Association between Clinical Characteristic and disease outcome Table 6: Association between Laboratory Parameters and disease outcome Table 7.Logistics regression model on the predictors of disease outcome Table 9 :Mean Survival time for the occurrence of the event

Conclusions:

Hypoalbuminemia and HIVAN are significant predictors of mortality among ESKD patients on haemodialysis

I have no potential conflict of interest to disclose.

I used generative AI and AI-assisted technologies in the writing process.
During the preparation of this work the author SOTUBO TOMIWA used GEMINI AI in order to rearrange my discussion in an orderly manner. After using this tool/service, SOTUBO TOMIWA reviewed and edited the content as needed and take(s) full responsibility for the content of the publication.