FASTING URINE OSMOLARITY IN RESIDENTS OF ENDEMIC AREA OF CKDU VISITING AIIMS RAIPUR

7 Feb 2025 12 a.m. 12 a.m.
WCN25-AB-4160, Poster Board= FRI-507

Introduction:

The Clinical presentation of CKDu is consistent with that of tubulointerstitial disease. Testing for tubular function like renal concentrating ability may aid in detection of CKDu before there is a drop in GFR. The following study aims to measure urinary concentration capacity in people with endemic area of CKDu with normal GFR visiting AIIMS Raipur.

Methods:

This cross-sectional study was conducted at the All India Institute of Medical Sciences (AIIMS), Raipur, Chhattisgarh, between June 2021 and May 2022. Adults more than 18 years of age, accompanying patients of CKDu getting admitted in the department of Nephrology were invited to participate in the study. The following laboratory tests were conducted: serum urea, creatinine, sodium, potassium, chloride, uric acid, random blood sugar, urine protein creatinine ratio, urine routine and microscopy and fasting serum and urine osmolality after 12 hours overnight fasting. The eGFR was calculated using Chronic Kidney Disease Epidemiology Collaboration‑CKD‑EPI 2009 equation for non‑blacks.

Results:

Ninety-three participants were included in the final analysis. The mean age of participants was 37.61 ±12.08 years. The mean fasting serum osmolality was 289.83 ± 6.49 mOsm/Kg. The mean fasting Urine Osmolality was 660.83 ± 200.15 mOsm/Kg. Forty-six (49.4%) participants had fasting urine osmolality below 600 mOsm/Kg and Twenty-three (24.7%) participants had between 600 to 800 mOsm/Kg. Forty-three (46.2%) participants had hypokalemia, fifteen (16.2%) had hyponatremia and fourteen (15.0%) had hypochloremia.

CharacteristicsTotal N=93

Male

56(60.2%)

Age (years) (mean ± SD)

37.61 ±12.08

Less than 30 years

31-40 years

41-50 years

51-60 years

More than 60 years

34 (36.6%)

28 (30.1%)

16 (17.2%)

11 (11.8%)

4 (4.3%)
 

Mean systolic blood pressure

Mean diastolic Blood Pressure (mm Hg)

Blood Urea (mg/dl)

Serum Creatinine (mg/dl)

eGFR (ml/min/1.73m2)

Serum Sodium (mEq/L)

Serum Potassium (mEq/L)

Fasting serum osmolarity (mOsm/Kg)

Fasting Urine Osmolarity (mOsm/Kg)

106.88 ± 10.25

67.58 ± 6.5

29.86 ± 5.09

0.845 ± 0.153

104.67 ± 15.60

137.85 ± 3.15

3.60 ± 0.47

289.83 ± 6.49

660.83 ± 200.15

Duration of stay in endemic area(years)

37.68± 12.05
   

Conclusions:

To conclude about 50% of seemingly healthy participants from the endemic belt of CKDu visit AIIMS Raipur have low mean fasting urine osmolarity after 12-hour overnight water deprivation.

I have no potential conflict of interest to disclose.

I did not use generative AI and AI-assisted technologies in the writing process.