Introduction:
There is a causal relationship between salt intake and hypertension, stroke, and kidney disease. However, whether reduced salt intake lowers blood pressure has been intensely debated
Methods:
In this prospective, open-label, randomized controlled trial, we examined the impact of a low-salt diet on blood pressure, renal function, and other metabolic parameters. Herein, 194 patients with chronic kidney disease (CKD) stage 1–3 were randomized into the low-salt (intervention) and control groups. The intervention group was provided a low-salt diet (1.5 g/day) for 3 months. The control group consumed their usual diet. Daily food intake was recorded. Renal function tests, 24-hour urinary sodium excretion, urinary protein, and serum calcium, phosphorus, and electrolyte levels were recorded monthly
Results:
Blood pressure decreased significantly in both groups; systolic blood pressure reduction at 3 months was significantly greater in the intervention group (-6.57, p<0.001) compared to the control group (-0.58, p=0.072). The mean reduction in 24-hour urine sodium excretion was greater in the intervention group, reaching a significant level at month 2 (-14.45, p=0.032). The mean reduction in estimated glomerular filtration rate was significantly higher in the control group.
Conclusions:
A sodium-restricted diet can reduce blood pressure and slow the progression of renal insufficiency in patients with CKD
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.