Introduction:
Pyelonephritis is the infection and associated inflammation of the kidneys. It's one of the serious infection which necessitates hospital admission and long antibiotic therapy.The pattern of organisms and its resistance is evolving with more resistant organisms resulting in greater mortality and morbidity .There is a deficiency of regional data regarding the profile of pyelonephritis. The study was conducted to study the profile of patients with pyelonephritis admitted to Nephrology department of a tertiary level hospital in south India.
Methods:
The study is a retrospective observational study spanning over the last 5 years . Consent of the patients were taken. The data of patients were retrieved from the hospital information records . Demographic details , details of admission , urinary culture profile , antibiotics used in treatment , patient outcomes were retrieved and recorded . The data was analysed using SPSS software.
Results:
We had a total of about 117 patients who were admitted with pyelonephritis over the last 5 years. The mean age group of our patients was 60.52 years. It consisted predominantly of females (68.4 %). 88.9 % of the patients suffered from diabetes mellitus with about 65 % of the patients affected were on insulin therapy. The most common symptom was flank pain which was seen in 62.4 % patients . The symptoms of dysuria was seen only in 15.4 % patients. 37.6 % patients required admission to the Intensive care unit. The most common organism causing pyelonephritis in our cohort was Escherichia Coli (35 %) followed by Klebsiella pneumoniae (12 %). 10 % of our cultures were positive for extended spectrum beta lactamase. Emphysematous pyelonephritis were seen in 17.1 % of our patients. Surgical procedure of Stenting was required in 25 % patients. One fourth of our patients required hemodialysis. we had a mortality of 12.8 % in the cohort. Reccurent pyelonephritis was seen in 16.2 % patients
Conclusions:
The profile of Pyelonephritis is rapidly changing with increasing prevalence of diabetes mellitus and irrational use of antibiotics. There is a shift in the patient population affected by pyelonephritis with more elderly being affected. The morbidity and mortality associated with multi drug resistant organisms is a big burden to health care and quality of life of patients. Rational use of antibiotic, healthy life style and good blood sugar control are crucial for preventing pyelonephritis.
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.