Introduction:
Background: Diabetic nephropathy is a leading cause of end-stage kidney disease globally. Genetic polymorphisms, as well as metabolic and hemodynamic homeostasis, are major factors in the development and progression of DN. Recent studies have shown that interleukin-10 polymorphic variants are associated with cytokine production, renal hypertrophy, and the onset of nephropathy.
Objectives: This study aims to investigate the role of interleukin-10 promoter polymorphism (-592A/C; -819C/T) in the association of chronic kidney disease in patients with diabetic nephropathy.
Methods:
In the present study, we used PCR-RFLP methods to genotype Interleukin-10 promoter gene polymorphism (-592A/C; -819C/T) in 100 patients with diabetic nephropathy (DN) and 98 control subjects. The DN patients were categorized into two groups: 39 individuals in CKD1 to CKD3 stages (early stage) and 61 individuals in CKD4 and CKD5 stages (advanced stage). We conducted a chi-squared test to assess associations.
Results:
A significant association was observed for IL 10 -592A/C (genetic model; AA vs CC, OR = 6.30; 95% CI = 2.24–17.7and P >0.001, recessive model; CC+AC vs AA, OR = 0.15; 95% CI = 0.06–0.38 and P > 0.001) polymorphism between the DN patients and control. However, there was no significance observed between the early stage and advanced stages of CKD progression.
Conclusions:
Present research shows a significant association of the -592A/C polymorphism with diabetic nephropathy. However, the studied polymorphisms did not contribute to the progression of CKD among diabetic nephropathy patients.
I have no potential conflict of interest to disclose.
I did not use generative AI and AI-assisted technologies in the writing process.