ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE COMPLICATED BY MALARIA DURING PREGNANCY WITH SUCCESSFUL MATERNAL AND FETAL OUTCOMES: A CASE REPORT

Introduction:

Acute kidney injury (AKI) is uncommon during pregnancy and anti-glomerular basement membrane (anti-GBM) disease as a cause is rare. 

Methods:

We report a case of a 30-year-old female, gravida 3, para 2+0, referred for deranged kidney functions during the investigation of anemia around 27-week pregnancy. 

Results:

Kidney biopsy revealed crescentic glomerulonephritis secondary to anti-GBM antibodies. Aggressive therapy with intravenous pulse steroids, pulse cyclophosphamide, and plasma exchange was started. Her kidney functions improved and anti-GBM titers were reduced to below 10 RU/ml. The illness was complicated by the development of malaria around 32 weeks of pregnancy. Although the malaria was promptly diagnosed and treated, it likely led to vaginal bleeding that required emergency cesarean section. She delivered a healthy live baby at 33 weeks of pregnancy. 

Conclusions:

This case highlights the need for aggressive therapy in improving the outcomes of anti-GBM disease and malaria in pregnancy.

I have no potential conflict of interest to disclose.

I did not use generative AI and AI-assisted technologies in the writing process.